Mark Abbott work email
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Mark Abbott personal email
An enthusiast for science with extensive experience in protein and cell science and their application to discovery of both small molecule and biological drugs. Most recently I discovered the enjoyment and satisfaction of applying these skills to set up and then grow a business together with a team of fantastically talented individuals.I started my research career purifying and studying central dopamine D2 receptors on a BBSRC CASE award in Philip Strange's lab at Nottingham University.I moved from there to Ten Feizi's lab at the MRC in Harrow where I purified, cloned the genes for and analysed structure function relationships of a group of mammalian beta-galactoside binding proteins.Since that time I have been working in the pharmaceutical industry managing teams and projects providing protein and cell science input and reagents into drug discovery projects for both small and large molecule pharmaceuticals. In addition I have significant experience managing and delivering technology improvement projects. I have a vast experience of recombinant protein expression and purification in all systems and of almost any class or size, intracellular or secreted. I left AstraZeneca in August 2014 and set up Peak Proteins at the BioHub, Alderley Park. We have grown from a business of just 2 people to one employing 50 people. We have moved to a new purpose built facility in Macclesfield in February 2022 and in April 2022 joined forces with Sygnature Discovery. Our expertise is in protein engineering, expression and purification and determination of protein structures using X-ray crystallography, protein NMR and cryoEM. I am an enthusiast for science. I like uncertainty and a challenge, trying to understand a problem and to think, read and by experiments find a way through. I like to be close to the data, either my own or working closely with others.
Peak Proteins Ltd, A Sygnature Discovery Business
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Managing DirectorPeak Proteins Ltd, A Sygnature Discovery Business Oct 2014 - PresentTytherington Business Park, Macclesfield, Cheshire, UkManaging Director and Founder of Peak Proteins Ltd a company with an expertise in multiple aspects of protein science (engineering, expression and purification and crystallography).
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Principal ScientistAstrazeneca Oct 2004 - Aug 2014Alderley Park, CheshirePrincipal Scientist in protein and cell scienceLeadership• Successful delivery of protein and cell reagents and expertise to support multiple small molecule and antibody drug discovery projects through management of small teams• Co-project leadership to enable discovery of novel antibodies for evaluation in pre-clinical osteoarthritis models• Successful project management of team delivering phenotypic screening strategy and novel assays to enable discovery of compounds inhibiting oncology linked transcription factor• Identification of detailed epitope map for a therapeutic polyclonal anti-TNF antibody by project management of multiple internal and external groups• Development of staff through coaching, mentoring and line management• Management of departmental strategy and activities through membership of local and global leadership teamsLaboratory Skills• Purification and analysis of multiple different classes of protein from all expression systems using all commonly used methods at scales from micro g to 2g for multiple different end uses. Particular expertise with extracellular proteins.• Development of a novel, robust and cost effective mammalian expression system for generating multiple different types of protein reagentsExternal presence• Successful scientific organisation of global external conference on recombinant protein technology at Alderley Park in November 2013• Proposal and management of multiple collaborations with academia and industry in protein and cell science• Multiple peer reviewed publications on diverse science• Invited speaker at international protein science meetings -
Team LeaderAstrazeneca Oct 1990 - Sep 2004Alderley Park, CheshireTeam Leader in Protein Science
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Post Doctoral FellowMrc Dec 1985 - Sep 1990HarrowPurification, cloning and structure/function relationships of mammalian galactoside binding lectins
Mark Abbott Skills
Mark Abbott Education Details
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Nottingham UniversityBiochemistry -
Bath University2:1
Frequently Asked Questions about Mark Abbott
What company does Mark Abbott work for?
Mark Abbott works for Peak Proteins Ltd, A Sygnature Discovery Business
What is Mark Abbott's role at the current company?
Mark Abbott's current role is Managing Director at Peak Proteins Ltd.
What is Mark Abbott's email address?
Mark Abbott's email address is ma****@****eca.com
What schools did Mark Abbott attend?
Mark Abbott attended Nottingham University, Bath University.
What skills is Mark Abbott known for?
Mark Abbott has skills like Drug Discovery, Protein Chemistry, Pharmaceutical Industry, Protein Expression, Cell, Purification, Oncology, Science, Life Sciences, Drug Development, Biochemistry, Antibodies.
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