Mark Struble Email & Phone Number

Malvern, Pennsylvania, United States

• Method development and analysis of novel drug substances and products• Experience with various separation methods of monoclonal antibodies including HPLC (SEC and IEX) and both reduced and non-reduced CE-SDS

Malvern, Pennsylvania, United States

• Supporting work at a client facility including materials inventory, sampling, growth promotion testing, testing samples, administrative tasks and proper documentation of work• Experienced in mass spectrometry analysis, qualified peptide mapping methods, protein digestion and the study of post translational modifications

Evanston, Il

Advisor: Professor Samuel I. Stupp• Designed self-assembling peptide structures with the capability of initiating oxygen and water stable free-radical polymerization reactions • Additional experience performing controlled polymerization reactions including PET-RAFT and ATRP• Assisted in the design and analysis of self-assembled biomimetic nanostructures for targeted drug delivery applications in collaboration with a diverse group of clinical researchers• Received the NIH Multidisciplinary Training Program in Child and Adolescent Health (TL1) Fellowship • Designed a directly injectable peptide based therapeutic for pediatric brain tumors that would reduce drug resistance and deliver the chemotherapeutic in tandem

Baltimore, Maryland Area

Advisor: Professor Thomas Lectka• Investigated intramolecular binding interactions of organofluorine compounds, potentially of use in enhancing targeted drug synthesis of fluorinated therapeutics• By analyzing reaction kinetics, reported the first evidence of the presence of a “fluoronium ion” intermediate in solution, a new class of halogen chemistry• Investigated unique fluorine/hydrogen bonding interactions in caged systems mimicking the noncovalent binding of fluorinated pharmaceuticals in protein binding pockets• Designed molecules where non-covalent interactions with fluorine atoms could be used to preferentially favor certain reaction pathways, sometimes even in the face of unfavorable conditions, such as stereochemical stress • Used physical organic chemistry techniques like reaction rate studies and isotopic labeling for the kinetic isotope effect to study reaction intermediates and probe non-covalent interactions such as hydrogen bonding, substituent effects and anion-pi interactions

Doctor Of Philosophy - Phd

Bachelor Of Science - Bs