Mark Struble Email & Phone Number

Malvern, Pennsylvania, United States

• Method development and analysis of novel drug substances and products
• Experience with various separation methods of monoclonal antibodies including HPLC (SEC and IEX) and both reduced and non-reduced CE-SDS

Malvern, Pennsylvania, United States

• Supporting work at a client facility including materials inventory, sampling, growth promotion testing, testing samples, administrative tasks and proper documentation of work
• Experienced in mass spectrometry analysis, qualified peptide mapping methods, protein digestion and the study of post translational modifications

Evanston, IL

• Advisor: Professor Samuel I. Stupp
• Designed self-assembling peptide structures with the capability of initiating oxygen and water stable free-radical polymerization reactions
• Additional experience performing controlled polymerization reactions including PET-RAFT and ATRP
• Assisted in the design and analysis of self-assembled biomimetic nanostructures for targeted drug delivery applications in collaboration with a diverse group of clinical researchers
• Received the NIH Multidisciplinary Training Program in Child and Adolescent Health (TL1) Fellowship
• Designed a directly injectable peptide based therapeutic for pediatric brain tumors that would reduce drug resistance and deliver the chemotherapeutic in tandem

Baltimore, Maryland Area

• Advisor: Professor Thomas Lectka
• Investigated intramolecular binding interactions of organofluorine compounds, potentially of use in enhancing targeted drug synthesis of fluorinated therapeutics
• By analyzing reaction kinetics, reported the first evidence of the presence of a “fluoronium ion” intermediate in solution, a new class of halogen chemistry
• Investigated unique fluorine/hydrogen bonding interactions in caged systems mimicking the noncovalent binding of fluorinated pharmaceuticals in protein binding pockets
• Designed molecules where non-covalent interactions with fluorine atoms could be used to preferentially favor certain reaction pathways, sometimes even in the face of unfavorable conditions, such as stereochemical stress
• Used physical organic chemistry techniques like reaction rate studies and isotopic labeling for the kinetic isotope effect to study reaction intermediates and probe non-covalent interactions such as hydrogen bonding.

Doctor Of Philosophy - Phd

Bachelor Of Science - Bs