Matthew Giese Email & Phone Number

Columbus, Oh, Us

Greater Columbus Area

-Serve as the subject matter expert to provide support to the executive, marketing, and sales teams regarding the content and applications of the crosslinker product portfolio -Collaborate with patent attorneys to develop the IP portfolio, execute competitive analyses, and establish freedom-to-operate-Provide SME support on bioconjugates and antibody-drug conjugates for sales calls, go-to-market campaigns, and marketing collateral-Design and host webinars for marketing campaigns that summarize the benefits of including PEG moieties in strategic linker-payload design to optimize the physicochemical properties, pharmacokinetic parameters, efficacy, and toxicity profiles of antibody-drug conjugates

Columbus, Ohio, United States

-Optimized multi-gram scale synthetic routes to hydrophilic bifunctional crosslinkers (NHS esters, maleimides, aminooxys, etc.) to improve quality, increase yields, and develop new products-Designed synthetic routes to radionuclide chelators (DOTA, DOTAGA), fluorophores (xanthenes and cyanaines), PEG-lipids (DSPE), and subsequent labelling reagents to develop new product lines-Developed multifunctional crosslinker architectures that were granted patent protection and developed multi-gram scale synthetic routes for their production and use in bioconjugates-Prepared peptide, antibody, enzyme, and phycoerythrin conjugates-Developed a scalable process for the purification of antibodies from antisera by fractionation, affinity chromatography, and ion exchange chromatography

Sacramento, California, United States

-Developed and validated quantitative assays (GC-FID and HPLC-UV) for secondary metabolites (terpenoids, cannabinoids, humulones, lupulones, etc.) in high-value crops-Developed qualitative assays (CG-FID and GC-MS) for plant lipids and sterols -Applied analytical assays to marker-assisted breeding/selection schemes that yielded novel plant cultivars and patents in the US, Europe, and Canada-Developed data visualization tools for internal applications and out-licensing to analytical laboratories

Indianapolis, Indiana, United States

-Employed SAR results, ADME screening, in silico tools, literature, and general medicinal chemistry knowledge to design ligands for nuclear hormone receptors-Designed synthetic routes that made extensive use of organometallic reactions such as Sonogashira, Suzuki, Stille, Heck, and Buchwald couplings, one of which was employed for the large-scale production of material for Phase I clinical trials-Contributed to internal SOPs, experimental design, publications, and patent filings

Ms, Organic Chemistry, 3.97/4.00

Dissertation titled Silyl Vinylketene Strategies in the Synthesis of Natural Products; Graduated Magna Cum Laude.

Ms, Physical Chemistry, 3.84/4.00

Dissertation titled Molecular Magnets; Graduated Magna Cum Laude.

Bs, Chemistry, 3.89/4.00

Senior Research Project titled The Electronic Transitions of Selenoformaldehyde; Graduated Magna Cum Laude.