Michael Sierk Email and Phone Number
Michael Sierk work email
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Michael Sierk personal email
I love analyzing data to gain insight into biology. Leveraging the immensely powerful bio- and computational technologies available today requires both a deep understanding of biology and insight into the strengths and weaknesses of computational methods. I have both.* I am a solutions-oriented bioinformatics scientist with a strong combination of cancer biology knowledge and broad computational expertise in NGS analysis, protein sequence and structure analysis, proteomics, and pathway analysis resulting in 14 manuscripts with 800 total citations. * I have excellent ability to thrive in cross-functional teams providing project management, data analysis and visualization, and fluent translation between biological and computational perspectives. * I'm an easy-going but persistent individual equally adept at viewing the big picture and diving into the details with excellent ability to communicate horizontally and vertically with colleagues of diverse personal and technical backgrounds.I'm a big Steelers and Pitt Panthers fan and I love pro and college football, basketball, and soccer. I played soccer and basketball and coached youth teams in basketball, soccer, and baseball. My newest sports passion is golf!
Essential Software Inc
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Senior BioinformaticianEssential Software Inc Feb 2022 - PresentGaithersburg, Maryland, Us* Apply structural biology knowledge to generate and assess Alphafold models of complexes of a transcription complex protein with various binding partners.* Develop a production-level WES variant calling pipeline using Nextflow for a longitudinal study of patients with germline mutations in a myeloid progenitor transcription factor, including a Shiny app for display of results.* Demonstrate collaborative teamwork by working with a diverse group of colleagues applying machine learning approaches in R to proteomic and clinical data from glioblastoma patients to identify pathway signatures resulting in a manuscript published in Frontiers in Oncology. * Project management skills and ability to innovate illustrated by development of a Python program to efficiently screen mutations in 3D resulting in a publication in BMC Bioinformatics.
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Bionformatics ConsultantThe Bioinformatics Cro Dec 2021 - PresentOrlando, Florida, UsAssisted clients with tasks such as improving a variant-calling pipeline and classifying colon-cancer samples based on RNAseq data. -
Bioinformatics ConsultantNephros Dec 2019 - Aug 2022South Orange, New Jersey, UsDeveloped an R Shiny app (https://msierk.shinyapps.io/sequapath) for counting Nanopore MinION reads from different microbial populations and displaying the results. (Github: https://github.com/msierk/SequaPath) Developing a pipeline for combining results from existing methods (minimap2, NanoCLUST) to classify 16S RNA reads at the genus and species level. Provide bioinformatics analysis of primers and probes for RT-PCR-based detection of microbial pathogens. -
Assistant ProfessorSaint Vincent College 2005 - 2021Latrobe, Pa, UsCollaborated with Shaun Mahony from Penn State and Esteban Mazzoni from NYU on a project evaluating transcription factor roles in promoting the development of neuronal subtypes in mouse neurons. I analyzed RNASeq data and CHiPseq data generated in the Mazzoni lab. This work was published in Frontiers in Neuroscience. (Aydin et al. 2022)Directed an undergraduate bioinformatics program, where I supervised students in their undergraduate research thesis activities, developed curricula, taught a variety of courses, and performed academic advising. I was also active in the Network for the Integration of Bioinformatics into Life Sciences Education (NIBLSE, www.niblse.org), an NSF-funded program. My colleagues and I constructed the first set of bioinformatics core competencies for undergraduate life science majors (Sayres et al., 2018). I have also been instrumental in implementing a new approach for developing teaching resources and training faculty (https://qubeshub.org/community/groups/niblse/resourcecollection/incubator).A selection of my key accomplishments includes: ⇨ Supervised over 25 diverse student-driven senior research projects including proposal, research, thesis, and poster presentation.⇨ NIBLSE Steering Committee and Resources Review Committee, an NSF-funded research coordination network, collaborating with diverse faculty across the country.⇨ Created a novel course in Biomedical Informatics where students analyze clinical trial data and utilize immunology, data mining and analysis, and databases. ⇨ Developed six new courses for department curriculum⇨ Authored or co-authored 5 manuscripts (180+ citations)⇨ Served as academic advisor to 100+ students; served on various committees; active member of the Chemistry and Interdisciplinary Science departments.⇨ Created and hosted the first Undergraduate Bioinformatics Education Conference six times. -
Postdoctoral Research AssociateUniversity Of Virginia 2001 - 2005Charlottesville, Va, UsWhile in the Pearson laboratory I led a research program focused on testing estimates of statistical significance produced by various protein structure comparison programs. My achievements include: ⇨ Analyzed ability of protein structure comparison algorithms to accurately predict whether two proteins are homologous; published work that has been cited more than 150 times.⇨ Screened numerous sequence and structure alignment programs for the ability to accurately detect homologous proteins (100+ citations).⇨ Wrote a review article on protein structure alignment algorithms (60+ citations).⇨ Served as an inaugural member on the International Society for Computational Biology’s Student/Postdoc Council -
Graduate Research FellowUniversity Of Virginia 1995 - 2001Charlottesville, Va, UsI utilized crystallographic analysis methods in Rastinejad laboratory to identify the sequence-specificity of DNA response elements for Rev-Erb and RXR nuclear receptors. This work resulted in published articles that have been cited more than 200 times collectively. I also served as the President of the Graduate Biosciences Society, a student-run organization responsible for hosting an outside speaker, organizing a graduate student poster session, and other activities.
Michael Sierk Skills
Michael Sierk Education Details
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University Of VirginiaBiophysics -
Rice UniversityPhysics (Biophysics Option)
Frequently Asked Questions about Michael Sierk
What company does Michael Sierk work for?
Michael Sierk works for Essential Software Inc
What is Michael Sierk's role at the current company?
Michael Sierk's current role is Experienced Bioinformatics Scientist | Data Analysis and Visualization | Machine Learning | Sports Fanatic.
What is Michael Sierk's email address?
Michael Sierk's email address is mi****@****ros.com
What schools did Michael Sierk attend?
Michael Sierk attended University Of Virginia, Rice University.
What skills is Michael Sierk known for?
Michael Sierk has skills like Bioinformatics, Teaching, Research, Biophysics, Biochemistry, Computational Biology, Protein Expression, Genomics, Protein Purification, R, Pcr, Molecular Cloning.
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