Nick Marsh Email & Phone Number

Waltham, Massachusetts, United States

Cambridge, MA

Cambridge, Massachusetts

• Lead a team of PhD Scientists and Research Associates responsible for using in vitro assays to characterize biotherapeutics from hit to lead
• Includes both Discovery Assays and Immunogenicity Risk Assessment groups

Waltham, MA

• Managed a team of PhD Scientists and Research Associates responsible for preclinical discovery activities and early-development including in vitro assays, PK, pharmacology and immunogenicity prediction

• Led a team of ten PhD Scientists and Research Associates responsible for the PK, pharmacology and GLP assays
• Project Leader for first joint Adnexus/BMS program to achieve ECN (candidate status, oncology program)

Cambridge, Massachusetts

• Managed a team of PhD Scientists and Research Associates responsible for the development and qualification of in vitro assays to support aptamer discovery and development
• Oversaw the development of cell-based and biochemical assays to support FDA filings
• Transferred cell-based and biochemical assays to and from CROs
• Support PK and Toxicology with in vitro assay and in vivo model data
• Project Leader on two programs, one in inflammation and one in neurology
• Provided in vitro assay data and technical reports for cardiovascular project IND filing

Cambridge, Massachusetts

• Managed a team of PhD Scientists and Research Associates responsible for the development and qualification of in vitro assays to support aptamer discovery and development
• Developed PD assays to support preclinical and clinical PK and toxicology
• Project Leader on two programs, one in inflammation and one in neurobiology
• Brought inflammation project to lead stage

• Managed Research Associates in the development and qualification of cell-based and biochemical assays to support aptamer discovery and development
• Project Leader on a cardiovascular program which was filed as an IND in 2004

Cambridge, MA

• Managed a team of Research Associates in the development and qualification of cell-based and biochemical assays
• Worked on the development of aptamers for target validation

• Established and supervised primary neuron functional assays in order to validate novel neuroprotective compounds
• These primary neuronal assays were comprised of four different neuronal types both of the Central and Peripheral nervous systems
• Established counter screens for drug validation
• Established neuronal apoptosis, cell proliferation and differentiation assays
• Managed a team of two Technologists

Doctor Of Philosophy (Ph.D.), Pharmacology

Dept. of Pharmacological and Physiological Sciences Advisor: H. Clive Palfrey, Ph.D. Dissertation: “Signal Transduction Events Mediated by.

Post Doc, Brain Tumor Research Center

Montreal Neurological Institute and Hospital Brain Tumor Research Center Advisor: David R. Kaplan, Ph.D. Research: Examined the role of.

B.A., Biology

Honors: Magna cum laude. Research: “Examination of the Role of the Optic Lobes as the Driving Oscillator in Locomotory Circadian Rhythms.