Nicolas Meier Email and Phone Number

Leading a new resin project with novel proprietary ligands to purify enveloped viruses like Lentivirus vectors and exosomes. Co-inventor of resin technology.Leading the second indication project until Anjarium’s restructuring from a therapeutic company to a Bioservice CDMO.Implementing project management and establishing a running project lifecycle management in a CDMO setup.

Co-inventor of new synthetic DNA, bioengineering and rare disease patents.Establishing synthetic non-viral DNA process from pDNA involving enzymes and rolling cycle amplification.Leading Lipid nanoparticle (LNP) manufacturing with mRNA, siRNA, pDNA and synthetic non-viral DNA, as well as, characterization, in-vitro screening and scale-up of formed LNPs.Setting up the production of Extracellular vesicles (EVs) and Lentivirus vectors including USP in bioreactors and… Show more Co-inventor of new synthetic DNA, bioengineering and rare disease patents.Establishing synthetic non-viral DNA process from pDNA involving enzymes and rolling cycle amplification.Leading Lipid nanoparticle (LNP) manufacturing with mRNA, siRNA, pDNA and synthetic non-viral DNA, as well as, characterization, in-vitro screening and scale-up of formed LNPs.Setting up the production of Extracellular vesicles (EVs) and Lentivirus vectors including USP in bioreactors and multi-step DSP.Expression assessment with reporter proteins or our target protein for rare disease indication projects.Coaching and supervising new employees. Show less

Executing DOEs for lipid nano particle libraries. Formulation of LNPs with nucleic acids (mRNA, siRNA and pDNA) by microfluidics. Executing quality control and batch release.Setting up the production of Extracellular vesicles (EVs) including USP in bioreactors and multi-step DSP.Expression assessment of LNPs and Hybridosomes (LNP fused with EVs) in cell-based assays with reporter proteins or target protein for our rare disease projects.Biosafety officer of Anjarium.

Prediction of bacterial enzyme mutation for higher activity and stability with homology models by Cyrus Bench software and testing engineered mutation in lab experiments.

Synthesis and purification of small molecules by multi-step reactions in MedChem department.Analysis of small molecules by NMR, MS, LC-MS, HPLC, TLC, GC, IR, mp/bp, refraction index.