Paul Seaman Email and Phone Number

3D Pharma Consulting Ltd is a UK-based pharmaceutical and biotech consultancy, dedicated to providing in-depth, real-world support around the 'threeDs'; Drug, Delivery and Development. We work with start-ups, university spin-outs and small-medium life sciences companies to bring novel and exciting drug products, processes and platforms to market. With particular expertise in drug delivery, formulation, analysis and pharmaceutical manufacturing, 3D Pharma Consulting Ltd integrates with your business to support a broad range of CMC aspects.

CMC lead across Midatech Pharma’s three drug delivery platforms, including Midatech’s Q-Sphera sustained delivery product pipeline where I led the development of controlled release parenterals from discovery to clinic. Working across a range of novel and established APIs from small molecule to biologics, I led a team of >10 biologists, formulation scientists, analytical scientists and pharmaceutical engineers in the development of novel drug products and readying Midatech's platform technologies for commercialisation.

Q Chip was acquired by Midatech in December 2014, with the merged companies listing on AIM as Midatech Pharma PLC (MTPH). I headed Midatech Pharma's Sustained Delivery pipeline, focussed on delivering peptide, protein and NCE therapies with extended duration of action, typically 1 to 6 months. These include oncology, endocrine and ophthalmic products across a mixture of full and abbreviated regulatory paths.

I led a multidisciplinary team responsible for many aspects of the early drug development programme, including scale up, formulation, analytical development, preclinical testing as well as clinical trials manufacture and clinical study planning. As part of this I also managed the outsourced components; identifying CROs and subsequent management of PK/safety studies and technology transfer to ensure a rapid and efficient development programme. I have co-authored non-clinical sections of regulatory submissions for the UK and cGMP-compliant Batch Manufacture Record for a complex sterile injectable product (aseptic manufacture). I have been able to employ my microbiology background (PhD) during the development and validation of the aseptic manufacturing process.I built a successful, motivated and innovative team of scientists and design engineers, which enabled Q Chip to achieve its goals and added significantly to company IP, know-how and value. Projects were targeted at enabling Q Chip to validate a proprietary production platform for sustained release parenteral formulations. The company has expertise in peptide, protein and NCE encapsulation, with depot formulations developed for the delivery of therapeutics over 1 month, 3 month and 6 month durations.

Development of rapid, nucleic acid-based in vitro diagnostics. I applied Q Chip's proprietary microencapsulation technology for the development of temperature-stable and simple to use reagent delivery systems for use in industrial, clinical and point-of-care IVDs.

Co-developed a high-throughput SNP genotyping platform for application in pharmacogenetics.