ESMO ID538954

Conducting bioinformatics analysis on diverse biological datasets, integrating structural and functional genomics, proteomics, and transcriptomics data to identify potential drug repurposing candidates. Collaborate with cross-functional teams to provide bioinformatics expertise, contributing to drug repurposing projects and supporting decision-making processes.

Supervisor: Dr Olusola Elekofehinti.Bioinformatics and Molecular Biology Lab.I currently work as a research associate. My duties include: 1. perform bioinformatics analyses on large-scale genomic, transcriptomic, and proteomic datasets of breast cancer using bioinformatics tools and machine learning algorithms such as deseq2 and sci-kit-learn to process and analyze high-throughput sequencing data to uncover novel biological insights; 2. develop and implement bioinformatics… Show more Supervisor: Dr Olusola Elekofehinti.Bioinformatics and Molecular Biology Lab.I currently work as a research associate. My duties include: 1. perform bioinformatics analyses on large-scale genomic, transcriptomic, and proteomic datasets of breast cancer using bioinformatics tools and machine learning algorithms such as deseq2 and sci-kit-learn to process and analyze high-throughput sequencing data to uncover novel biological insights; 2. develop and implement bioinformatics pipelines using python for variant calling from next-generation sequencing data and utilize tools like bwa-mem and GATK for alignment and variant identification; 3. design and conduct biochemical assays (DNA extraction, PCR, western blotting, gel electrophoresis) to validate our computational results; 4. assist in the preparation of research proposals, manuscript writing, and grant applications. 5. train undergraduate students in in-silico drug design using tools such as auto-dock, Pymol, and Schrodinger suite, and mentor students in Python and r programming for analyzing cancer genomics data, including next-generation sequencing data, gene expression profiling, and pathway analysis. 6. Presented work at international conferences including AACR, ISCB, ESMO. Show less

• Performed quality control analysis using affy QC package, identified and removed outlier samples (Trimmomatic).• Alignment of reads with reference genome with STAR, HISAT2• Variant calling with GATK• Normalized dataset using Gcrma package.• Visualized data using heatmaps, PCA, histograms, and box plots with the help of ggplot2 and enhanced volcano package.

Processing and analyzing genomic data using various bioinformatics tools and software.Performing data quality control, data cleaning, and data integration.Staying up-to-date with current genomic and genetic research

Centre for Bio-Computing and Drug Development, Department of Biochemistry,I worked as a graduate research assistant, where my responsibilities included; 1. Design and execute experiments to extract, isolate, and purify phytochemicals from plant materials using techniques like solvent extraction, column chromatography, and HPLC. 2. Biochemical assays such as PCR and rt-PCR were performed to analyze the effects of phytochemicals on gene expression levels in cancer pathways, antioxidant… Show more Centre for Bio-Computing and Drug Development, Department of Biochemistry,I worked as a graduate research assistant, where my responsibilities included; 1. Design and execute experiments to extract, isolate, and purify phytochemicals from plant materials using techniques like solvent extraction, column chromatography, and HPLC. 2. Biochemical assays such as PCR and rt-PCR were performed to analyze the effects of phytochemicals on gene expression levels in cancer pathways, antioxidant response, and inflammatory response. 3. Performed in silico screening of natural product databases such as NPACT, and NANPDB to identify phytochemical compounds with potential bioactivity against specific protein targets. 4. Conduct literature reviews, assist in the preparation of research proposals, grant writing, and submit manuscripts for publication in peer-reviewed scientific journals. 5. Analyze experimental data using Python, R, and bioinformatics tools such as GATK, BLAST, and BOWTIE for variant calling, and sequence alignment respectively. 6. Taught undergraduate laboratory sessions, providing hands-on training in preparing biochemical assays and visualizing experimental data using MATPLOTLIB and GGPLOT2 to effectively communicate data and results.Carried out research using in silico experiments (Bioinformatics) and in vivo procedures via molecular Biology involving DNA, RNA, protein isolation, and quantification Show less

Prepare primers and probes. Isolate and purify DNA, RNA, and proteins.Carry out the conventional molecular biology tests, as well as cell culture

Performs diagnostic testing on urine, sputum, semen, and stool. Conducts blood test and perform blood counts Analyze body fluids using microscope.