Rebecca Edwin Email & Phone Number

• Involved in the development of gene therapy for Rare diseasesPrimarily responsible for:
• Designing and development of AAV based gene therapy constructs for the treatment of Methyl Malonic Acidemia (MMA)
• Generation of knockout cell lines using CRISPR/Cas9 Technology for the systemic evaluation of AAV based gene therapy in cell models

Hyderabad, Telangana, India

• Carried out detailed investigation on the role of PIMT, an upstream regulator in the PPAR gamma transcriptional machinery, in insulin sensitive adipose tissues
• Conducted studies focused on adipogenesis and lipid metabolism by developing lentiviral mediated PIMT knockdown adipocytes followed by transcriptomics
• Validated invitro findings in vivo in an obese mice model followed by human adipose tissues
• Simultaneously collaborated with other team members in experiments conducted on hepatocytes, macrophages and pancreatic beta cells, collectively demonstrating that PIMT is a potential therapeutic target for insulin.

Hyderabad, Telangana, India

• Screening and Development of potential small molecule inhibitors against Tuberculosis
• Actively involved in the early preclinical development of a novel small molecule inhibitor against Mycobacterium tuberculosis.
• Performed cloning and purification of recombinant Chorismate mutase enzyme
• Carried out cell based assays to screen potential inhibitors

Bangalore

HPLC and Mass Spec analysis of Post Translational modifications in Monoclonal antibodies.

Worked in the area of bioinformatics and Molecular biology.

Doctor Of Philosophy - Phd, Cell/Cellular And Molecular Biology

Master'S Degree, Pharmaceutical Biotechnology

M.Pharm in Pharmaceutical biotechnology

Pharmaceutical Sciences

Education record