Ryan Longchamps Email & Phone Number

Washington, Dc, Us

• Generated simulation data and evaluated the efficiency of a novel summary statistics-based cross-ancestry fine-mapping method compared to pre-existing methods.• Performed cross-ancestry fine-mapping and functional annotation in 100,000 individuals across 30 phenotypes from the UK Biobank, BioBank Japan and Taiwan Biobank.• Collaboratively contributed R and Python code for the development of a GWAS summary statistics QC pipeline.

Baltimore, Md

• Performed genome wide association study (GWAS) in 470,000 individuals for mitochondrial DNA copy number as lead analyst for the CHARGE consortium in collaboration with 15 cohorts across the US and Europe. • Employed Mendelian Randomization and Polygenic Risk Scores to elucidate the relationship between mitochondrial DNA copy number and Cardiovascular Disease.• Developed algorithms to calculate mitochondrial DNA copy number from genotyping arrays, whole genome and whole exome sequencing data that contributed to 9 published manuscripts and 2 publications in preparation.• Demonstrated an association of mitochondrial heteroplasmy with overall mortality and Cardiovascular disease in 20,000 individuals from the CHARGE consortium.• Optimized high throughput mitochondrial DNA sequencing enabling 384x multiplexing within a single flow-cell.• Directed development of allele-specific CRISPR-Cas9 cell lines targeting genes affecting mitochondrial DNA replication efficiency and fidelity.

Bethesda, Md

• Investigated the use of microRNAs measured from whole blood as minimally invasive biomarkers for non-alcoholic fatty liver disease progression.• Optimized labrotory Ion Torrent Personal Genome Machine sequencing protocol for gut microbiome samples.

Doctor Of Philosophy (Phd), Human Genetics

Bachelor Of Science (B.S.), Neurobiology And Physiology