Samuel Jacques Email & Phone Number

Montreal, Qc, Ca

Toronto, Ontario, Canada

Boston, Massachusetts, États-Unis

- Identified and helped develop new technologies to drive next-generation RNA platformdevelopment (mRNA and circular RNA).- Provided technical direction and guidance on improving partner RNA therapeutics to ensureproject success (In vitro transcription (IVT) optimisation up to 250 mg RNA).- Collaborated cross-functionally on product characterisation and in-process testing of RNAmolecules (purity, capping efficiency and dsRNA content).- Wrote and reviewed in-depth… Show more - Identified and helped develop new technologies to drive next-generation RNA platformdevelopment (mRNA and circular RNA).- Provided technical direction and guidance on improving partner RNA therapeutics to ensureproject success (In vitro transcription (IVT) optimisation up to 250 mg RNA).- Collaborated cross-functionally on product characterisation and in-process testing of RNAmolecules (purity, capping efficiency and dsRNA content).- Wrote and reviewed in-depth technical SOPs, ensuring products were consistently produced andcontrolled to meet quality standards. Show less

Boston, Massachusetts, United States

Boston, Massachusetts, United States

- Designed strains (yeasts and bacteria) to optimise the production of chemicals, enzymes andother proteins (PCR, Gibson assembly, CRISPR).- Developed suitable cultivation conditions and assays for screening the performance of thestrains.- Performed arrayed screens including thousands of strains using automation tools.- Tested the metabolic and physiological performance of the strains using multi-omics.

Montreal, Quebec, Canada

- Established a high-throughput (HTP) yeast-based assay to screen for inhibitors of the SARS-CoV-2 virus, the causative agent of COVID-19.- Optimized biochemical assays to validate initial hits.- Discovered inhibitors of the SARS-CoV-2 Main protease and NendoU endonuclease for the development of antiviral treatments against COVID-19.- Used the artificial intelligence (AI) algorithms of Valence Discovery to generate analogues based on the structure of the initial hits for… Show more - Established a high-throughput (HTP) yeast-based assay to screen for inhibitors of the SARS-CoV-2 virus, the causative agent of COVID-19.- Optimized biochemical assays to validate initial hits.- Discovered inhibitors of the SARS-CoV-2 Main protease and NendoU endonuclease for the development of antiviral treatments against COVID-19.- Used the artificial intelligence (AI) algorithms of Valence Discovery to generate analogues based on the structure of the initial hits for structure-activity relationship (SAR) studies.The internship was sponsored by Mitacs. Show less

Quebec, Canada

- Supervised a COVID-19 diagnostic lab in Northern Quebec.- Trained the technicians to accomplish daily tasks.- Processed the samples (i.e. RNA extraction and qRT-PCR).- Interpreted the results.- Took appropriate actions when a positive case was found.

Région De Montréal, Canada

- Produced new-to-nature natural products with antibacterial activity against S. aureus and mycobacteria.- Designed libraries of yeast artificial chromosomes (YACs) for Saccharomyces cerevisiae to create biosynthetic pathways using automated workflows.- Performed metabolic engineering on S. cerevisiae to overcome bottleneck using the CRISPR/Cas9 system and homologous recombination.- Optimized cultivation conditions and developed high-throughput screening (HTS) assays for synthetic… Show more - Produced new-to-nature natural products with antibacterial activity against S. aureus and mycobacteria.- Designed libraries of yeast artificial chromosomes (YACs) for Saccharomyces cerevisiae to create biosynthetic pathways using automated workflows.- Performed metabolic engineering on S. cerevisiae to overcome bottleneck using the CRISPR/Cas9 system and homologous recombination.- Optimized cultivation conditions and developed high-throughput screening (HTS) assays for synthetic natural products (SynNPs) with activity against Mycobacterium tuberculosis (MTB), P. falciparum (malaria) or S. aureus.- Analyzed and interpreted data from HTS.- Used different next-gen sequencing technologies to investigate productive strains (i.e. Illumina NextSeq 550 and Oxford Nanopore).- Organized experiments to meet tight deadlines.- Prepared presentations regularly to share results with international collaborators.- Managed a database. Show less

Région De Montréal, Canada

- Creation of synthetic signalling pathways by engineering proteins with multiple domains.

Sherbrooke

- Studied the folding of the adenine riboswitch using single-molecule Fluorescence Resonance Energy Transfer (smFRET).- Discovered a structural intermediate involved in ligand recognition.

Sherbrooke

- Studied the relaxase TraI, which is essential for conjugative DNA transfer in bacteria.

Ph.D., Molecular Biology

- Named to the Rector’s Honours List. - Established the mechanism of action of the preclinical anticancer compounds ONC201 and ONC212.

Graduate Diploma, Business Administration And Management

Summer School On Medicines, Pharmaceutical Sciences

50-hour training program on drug discovery, development and market access

Master Of Science (M.Sc.), Molecular Biology

- Created a platform for the generation and screening of new-to-nature compounds for the discovery of new antibacterial leads against.

Bachelor'S Degree, Molecular Biology

As part of the Coop program, I completed three internships in professional environments.