Santanu Raychaudhuri personal email
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I have been cultivating biological sciences and their technologies through cutting edge research and development using their applications in academics and industry with an aim to improve human health.Making an immediate contribution in a challenging leadership position in Biotechnology or Pharmaceutical environments including Academics that would utilize my extensive experiences in project management, leadership, both performing and leading scientific experiments. My main goal is the drug development, particularly in Anti-Viral therapeutics, Cancer therapeutics and Metabolic Diseases. Currently I am involved in preclinical drug development in University-Industry set up and collaboration.Strength Includes: • Preclinical studies, mechanism of actions, cell-based assays and therapeutics • Background in molecular biology, biochemistry, cell biology, Virology and immunology • Details in vitro and in vivo studies: experiences in rodent animals • Detailed understanding in the drug development processes and clinical trials • Extensive experiences in scientific research processes, writings and federal regulations • Extensive hands on experiences in research and development including scientific leadership • Working experiences in cancer biology, and target pathways;• Expert in exploring cellular and molecular mechanisms in cancer and metabolic pathways • Expert in cell culture, cell-based assays, biochemical and immunological techniques • Self-motivated and demonstrated leadership in therapeutic virus-mediated cancer research• Extensive experiences in various Viral Vectors manipulations for vaccine and drug discovery research• Design, manipulations, and expressions of large biologic molecules including monoclonal antibodies • Experienced in diagnostic & bio-marker studies for infectious and metabolic diseases by Exosome-pathway • Computer handling in R & D and statistical analyses• Excellent written and oral communication skills
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Associate DirectorVirovek, Inc. Nov 2021 - Oct 2023United StatesGene Therapy Vectors -
ProfessorDepartment Of Biotechnology, Government Of India Jul 2015 - Dec 2018North East Universities, IndiaResearch & Teaching Graduate and Undergraduate University Students -
Professional ScientistUcla Aug 2005 - May 2014Ucla School Of MedicineMammalian positive strand RNA virus gene regulation: Molecular targeting of the anti-virus therapeutics Development of Hepatitis C NS5A inhibitors. The molecular etiology of hepatocellular carcinoma (HCC) caused by hepatitis C. Mechanisms of actions of IRES (Internal Ribosome Entry Sites) mediated RNA translation. Development of artificial small IRES element of high biological activity: construction of HCV genome harboring artificial IRES directing high level of protein synthesis and thus directing synthesis of virus in cell culture systemCellular IRES: GLUT, VEGF and TFIID. Molecular chaperones in the cellular RNA translation in the event of stress conditions. Mechanism of actions of molecular chaperones in both viral and cellular RNA translations Epigenetic control of gene expression in higher eukaryotes. Involvement of genetic and epigenetic events in normal and pathophysiological conditions in mammals The micro-RNA mediated gene silencing: Mechanism of actions of micro-RNA in the inhibition of the specific cellular RNA translation under stress conditionsThe role of microRNA in HCV development and progression in host liver cells. Role of micro-RNA in the stem cells proliferation and differentiationHCV-mediated liver carcinogenesis. Hepatic Stem cells and how HCV affects this group of cells in normal and pathophysiological conditionsMechanism of actions of HCV-IRES inhibitors and the proposition of gene therapy in HCC patientsThe plant anti-oxidant Quercetin mediated inhibition of hepatitis C. Mechanism of actions of this group of inhibitor in the host-cell interaction. The role of Quercetin in HCV morphogenesis. The encapsidation signal for hepatitis C. The mechanism of action of HCV encapsidation.The mechanism of HCV assembly/morphogenesis of Hepatitis CViral mediated (HCV, HIV, and DNA viruses) Thymidine Kinase membrane upregulation: TK-1 mAb therapy as an anti-cancer drug -
Postgraduate Researcher; Microbiology, Immunology And Molecular GeneticsUcla Jun 2002 - Jul 2005Greater Los Angeles AreaMolecular virology in positive-strand RNA viruses and the mechanism of actions of its inhibitors. Translational control of gene expressions in mammals.Research Topics:Mammalian positive strand RNA virus gene regulation in replication, transcription and translational control with the emphasis on HCV and Polio virus. Molecular targeting of the anti-virus therapeutics in HCVDevelopment of Hepatitis C NS5A inhibitors. The molecular etiology of hepatocellular carcinoma (HCC) caused by hepatitis C. Expression and purifications of all structural and non-structural HCV proteins in E. coli and Hepatic cell-lines. Structure-function analysis of Core and NS5A in-vitro and in-vivo. Signal transduction pathways modulated by these regulatory proteins of the host systems.Mechanisms of IRES (Internal Ribosome Entry Sites) mediated RNA translation. Translational inhibitors for positive strand RNA viruses. Development of artificial small IRES element of high biological activity for functional analysis of translational regulation of protein synthesis: construction of HCV genome harboring artificial IRES and/or mutations directing high level of protein synthesis and thus high-titer virus.Cellular IRES: VEGF and TFIID. Molecular chaperones in the cellular RNA translation in the event of stress conditions. Mechanism of actions of molecular chaperones in both viral and cellular RNA translations.Publications:Raychaudhuri S, Fontanes V, Barat B, Dasgupta A (2009). Cancer Research. 69: (5). March 1, 2057-2063. Izumi RE, .... Raychaudhuri S, and Dasgupta A (2004), Journal of Virology, 78 (7): 3763-76. Raychaudhuri S, Fontanes V......Dasgupta A (2006). BBRC, 350 (3), 788-95. Kundu K, Raychaudhuri S, Tsai W, Dasgupta A (2005), Journal of Virology, 79(15):9702-13. Sharma*, R., Raychaudhuri, S*. and Dasgupta, A (2004). Virology, 320, 195-205. *equal contribution Weidman MK, Sharma R, Raychaudhuri S, ..... Dasgupta A (2003). Virus Research, 95, 75-85. -
Sloan-Kettering Rockefeller Institute; Sr. Research TechMemorial Sloan-Kettering Cancer Center Nov 1998 - Jun 2001New York CityIn vitro assembly of replication complexes using baculovirus purified proteinsUnderstanding of cell-cycle regulation of DNA replication initiation and mitosis progressionCell biology of replication initiation proteins and their impact on cell cyclePublications:Fien K, Cho YS, Lee JK, Raychaudhuri S, Tappin I, Hurwitz J. (2004), Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. Journal of Biological Chemistry, 279(16):16144-16153.Keong-Yeop Moon, Daochun Kong, Joon-Kyu Lee, Santanu Raychaudhuriand Jerard Hurwitz (1999), Proc. Natl. Acad. Sci. (USA), 96(22), 12367-72. Identification and reconstitution of the origin recognition complex from S. pombe.Santanu Raychaudhuri (1999). Cold Spring Harbor Laboratory. The origin recognition complex of S. pombe: the importance of Orc3 and Orc6 subunits. Santanu Raychaudhuri (1999). Cold Spring Harbor Laboratory. Purification of the origin recognition complex from S. pombe.
Santanu Raychaudhuri Skills
Santanu Raychaudhuri Education Details
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Jadavpur University & Uconn Health CenterBiochemistry And Molecular Biology -
Clinical Trial Management
Frequently Asked Questions about Santanu Raychaudhuri
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What schools did Santanu Raychaudhuri attend?
Santanu Raychaudhuri attended Jadavpur University & Uconn Health Center, Uc San Diego.
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