Sari Grossman Email & Phone Number

Greater Chicago Area

• Design and implement observational research studies that fill evidence gaps to support launch products. In particular, execute Statistical Analysis Plans (SAP) to contribute to peer-reviewed publications.• Run exploratory analyses to close evidence gaps for pipeline products for clinical portfolio decisions.• Conduct ad hoc projects, as needed, to support Global Value Evidence and Patients Insights function.• Translate analyses results into insights that can be understood by non-Health-Service research experts. In particular, develop visual displays of results to create user-friendly outputs and tools.• Identify any potential data issues and resolve them with data providers.• Run quality assurance and check analyses to ensure the scientific rigor of Lundbeck’s publications derived from the analyses.

Ann Arbor, Michigan, United States

PI: Dr. Krishna Rao• Wrote and submitted a clinical trial study protocol to the IRB to conduct a retrospective observational study on IBD patients infected with C. difficile• Designed R programming language to statistically analyze and model clinical data involving the intersection of C. difficile infection and flare in IBD patients• Shadowed clinical rounds and medical procedures in the gastroenterology department at Michigan Medicine to gain patient interaction exposure• Oral presentation

Supervisor: Dr. Supra Verma• Directed literature review on the association of gout and other disease states to guide next steps in clinical investigation and pharmaceutical management of disease• Applied R programming language to analyze particular vitals among treatment and placebo arms in clinical trials sponsored by Horizon Therapeutics• Oral presentation

Ann Arbor, Michigan, United States

PI: Dr. Pavan Reddy• Implemented mouse models and mammalian cell culture to study novel pathogenic mechanisms in Graft Versus Host Disease that has context in improving outcomes in steroid refractory GVHD and conventional immunotherapy resistant cancer• Demonstrated proficiency in ELISA, western blot, mixed lymphocyte reaction, and cytotoxic T lymphocyte based assays• Oral presentation

Ann Arbor, Michigan, United States

• Designed lesson plans and taught concepts to aid in mastery of course material

Ann Arbor, Mi

PI: Dr. David Sherman• Independent project involved probing suspected hydrogen bonding interaction of a multifunctional bacterial cytochrome P450 monooxygenase and its substrate through site-directed mutagenesis to characterize and improve efficiency of a key step in its iterative C-H functionalization pathway• Utilized LC-MS and kinetic experiments to analyze P450 reaction products obtained from biotransformation reactions and determined binding affinity parameters• Poster presentation • Through the NSF-CCI Center for C-H Functionalization

Ann Arbor, Mi

PI: Dr. John Montgomery• Optimized core scaffold synthesis of an analog of natural substrate for a multifunctional bacterial cytochrome P450 monooxygenase in order to study the effect of substrate structure on activity• Combined substrate engineering experimental data with previous protein engineering work to broaden understanding of potential novel antibiotics that can be synthesized by manipulating catalytic activity and substrate selectivity of the enzyme• Through the NSF-CCI Center for C-H Functionalization

• Developed protein and cell based assays to examine and support potency and mechanism of action studies of potential novel biologic drugs, as part of the Bioassay Center of Excellence team within Biologics Product Development• Conducted reporter gene and cytotoxicity assays and cultured mammalian cell lines to study immuno-oncology drug resulting in data to guide purity analysis• Oral Presentation

Menlo Park, California

PI: Dr. Cornelius Gati, Dr. Soichi Wakatsuki• Imaged protein found in inner membrane of mycobacterium tuberculosis in 2D and 3D with cryo electron microscopy to aid in structural understanding for drug development• Explored biochemical properties of target protein by developing liposome assays that monitor flippase activity in varying chemical environments• Oral Presentation• Through the Science Undergraduate Laboratory Internship funded by the U.S. Department of Energy

Atlanta, Georgia

PI: Dr. Facundo Fernandez, Dr. Nicholas Hud• Examined non-covalent interactions of diphenylalanine (FF) through ion mobility-mass spectrometry to optimize instrument parameters• Applied FF studies to analysis of depsipeptide interactions through native mass spectrometry to identify depsipeptide function on prebiotic earth• Poster and oral presentations• Through the NSF-CCI Center for Chemical Evolution and Georgia Tech Research Experience for Undergraduates program

PI: Dr. Jorge Iñiguez-Lluhí• Conducted FRET assays with guidance of graduate student to isolate small molecule inhibitors of the enzyme SENP1 • Cultured mammalian cell lines to be used to study the SUMOylation pathway and the effects of SENP1 inhibition in advanced stages of prostate cancer• Poster presentation • Through the Undergraduate Research Opportunities Program at University of Michigan

West Bloomfield, Mi

• Shadowed a neurology practice to learn clinical terminology and understand relations between clinical professionals and patients• Assisted the Oakland County medical examiner in performing autopsies and preparing, processing and analyzing histology samples• Through the Medical Mentorship program at West Bloomfield High School, MI

Master Of Science - Ms, Microbiology And Immunology

Activities and Societies: Crohn's and Colitis Student Initiative

Bachelor Of Science - Bs, Biochemistry

Activities and Societies: American Chemical Society University of Michigan Chapter, Undergraduate Science Journal Club, Undergraduate.