Michael Sachs, Ph.D Email & Phone Number

San Francisco, CA, US

Providing transparency and strategic insights to optimize decision-making for the R&D computational communityWe partner with Computational Sciences colleagues in 3 areas to clarify questions like…PORTFOLIO- How can my work fit into the big picture? What are we investing in?STRATEGY- How should we determine our areas of focus? How do we create a.

STRATEGY*Led an executive-sponsored company-wide informatics strategy*Committee manager for an R&D-wide strategic informatics steering group*Framed prioritization for AI project portfolio

PRODUCT MANAGEMENT*Conception, development, and integration of a RWD-enabled digital tool to inform clinical trial design*Business case defined in collaboration with internal/external clinical and computational experts*Oversaw 2 pilot deployments with clinical-stage drug development teams

PORTFOLIO SUPPORT*Cross-functional analyses for senior R&D leadership*Track portfolio performance and associated decision-making processes*Risk assessmentDRUG DEVELOPMENT TEAM SUPPORT*Strategic adviser for scenario planning*Risk assessment*Disease/platform strategies

• Analyzed portfolio performance for trends and decision accuracy for presentation to senior management
• Built an investment database from cross-department sources for insight discovery & hypothesis testing
• Designed and rolled out a clinical trial tracker to inform management on trial-expansion decisions
• Built a risk-adjusted valuation model including Monte Carlo simulation for scenario testing
• Assisted in prioritizing new investment proposals to inform strategy/budget planning for 2015
• Participated in gathering internal key opinion leaders’ perspective on pricing oncology combo-therapies

• Ph.D. in epigenetics, stem cells, and reproductive biologyMentor: Miguel Ramalho-Santos, Ph.D.
• Conducted independent risk assessment analysis for project selection and focus
• Developed computational skills for in-depth analysis & interpretation of Next Generation Sequencing data
• Supervised and mentored the technical and scientific advancement of a Masters student for 2 years
• Peer-reviewed 4 articles for top scientific journals
• Rated 4.5 out of 5 for teaching a UCSF histology laboratory course

Directed the structural biology efforts on assigned drug targets. This included all technical aspect from cDNA design to processing of X-ray crystallography data.

Conducted recombinant protein expression, using E. coli and Baculovirus/insect cell expression systems, for screening (2-5ml) and large-scale production (500ml-10 L) in bioreactors.

Doctor Of Philosophy (Ph.D.), Biomedical Sciences, General

Bachelor Of Science (Bs), Biomedical/Medical Engineering