Sean Mack Email & Phone Number

Gaithersburg, MD, US

Gaithersburg, Maryland, United States

• Contribute to the process development of CHO cell lines producing clinically relevant therapeutics
• Develop metabolic and machine learning models to predict optimal feeding strategies
• Mentor associates, interns, post-bac, and post-doc on individual research projects
• Lead harmonization effort across team. Led to the generation of ~12 new SOPs and improved data consistency/hygiene

Gaithersburg, Maryland, United States

• Contribute to the process development of CHO cell lines producing clinically relevant therapeutics
• Leverage data analysis and metabolic modeling to understand lactate shift mechanism
• Design and lead the execution of experiments with a 6-member team to ensure data relevancy and quality
• Co-author standard operating procedure for Ambr250 operation
• Mentor a post-baccalaureate fellow on experimental and computational techniques and professional development

College Park, Maryland

• Completed dissertation research under Dr. Daniel Dwyer and Dr. Ganesh Sriram
• Identified the metabolic phenotypes of antibiotic resistant E. coli with and without antibiotic stress
• Developed computational pipeline to integrate transcriptomics, metabolomics, and 13C isotope labeling data with a genome-scale metabolic model
• Designed continuous growth experiments and collected multi-omics data (collaboration with Pacific Northwest National Laboratory)
• Co-developed two computational tools, NetRed and NetFlow, that improve data analysis by reducing model complexity
• Coordinated with external partners on joint projects, including responsibility and expectation setting, frequent communication, and review and provision of feedback on results

Wilmington, DE

• Completed senior thesis under Dr. Matthew Butchbach and Dr. Prasaad Dhurjati
• Quantified impact of cAMP activators in spinal muscular atrophy fibroblasts using immunofluorescence
• Developed a quantitative model of cAMP pathway to predict treatment mechanisms

Newark, DE

• Conducted research under Dr. Millicent Sullivan
• Formulated poly(Ethylene Glycol) conjugates for siRNA Delivery

Newark, DE

Conducted quality control tests on customer fuel samples.Formulated new fuel additives to improve performance

Doctor Of Philosophy - Phd, Chemical And Biomolecular Engineering

Activities and Societies: Graduate Student Government; Chemical Engineering Graduate Student Association

Honors B.S. With Distinction, Chemical Engineering

Activities and Societies: Zeta Beta Tau, Varsity Men's Rowing, Tutor

High School Diploma