Sergey Laptenok Email and Phone Number

Label-free based on vibrational spectroscopy and multi-photon methods (coherent Raman microscopy, SHG, THG) and fluorescent imaging methods applied to biology and medicine. Ultrafast dynamics of complex condensed phase systems and interfaces. Role of the protein dynamics in its functions. Development and application of ultrafast methods in spectroscopy and microscopy (IR/visible femtosecond pump-probe spectroscopy, time-resolved fluorescence spectroscopy, Fluorescence Lifetime Imaging Microscopy)​. Development of methods and applications for Global and Target analysis of time-resolved spectroscopy and microscopy data. Developing an application called Glotaran: glotaran.org

The aim of the project is the complete characterization of the primary events underlying the operation of blue light sensing proteins, especially flavoproteins, using ultrafast spectroscopy (IR, Vis, fluorescence) to characterise the molecular dynamics.

Developing timeresolved fluorescence setup based on the kerr gating.

Developing a cross platform and open source graphical user interface (GUI) to the R package TIMP, called TIMPGUI. http://timpgui.org

Micro-spectro-scopic techniques (combining microscopy with spectroscopy) can provide direct information on molecular interactions and dynamic events involving biomolecules with minimal perturbation of cellular integrity and function and they are particularly useful for studying live cells.The aim of the project is to develop a multidimensional fluorescence analysis methods dedicated to improve the visualization and the quantitative analysis and physical interpretation of complex spectral, spatial and time-resolved data sets.