Dr. Shailesh Kumar Samal Phd Med, Phd Biochem Email and Phone Number
In a nutshell, passion and diligence are two traits that I believe reflect me as an individual. I enjoy using my skills to generate new ideas and devise feasible solutions to briefly address relevant problems in translational research. Research with first-hand implication on public health had always been pre-eminent for me. I had received 2 prestigious International fellowships to study in USA and Portugal. I have worked with Prof. Oliver Smithies (Nobel laureate for Medicine-2007) for 6 months at University of North Carolina, Chapel-Hill, USA. My research goals were more focused towards genetically engineered mouse models to investigate the role of blood pressure and diabetes regulating genes in metabolic syndrome and cardiovascular diseases using gold nanoparticles. I got another scholarship as a master mobility student for dissertation at FEUP, Universidade Do Porto, Portugal for 10 months under Erasmus Mundus Euphrates scholarship programme with Dr. M Simões. I have Co-founded a company called “InkRUDS Biotech”. and also received many national recognitions in India. I am a double doctorate in the field of Medicine and Biochemistry from Karolinska Institutet and Maastricht University under INTRICARE-Marie Curie Project from European Commission. Received several awards and recognition during my PhD in the field of Clinical Immunology, Vaccine development and Innovation. Inflanova AB is the recent venture co-founded by me and Prof. Johan Frostegård, focusing on development of Vaccines for Chronic inflammatory Diseases.
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Adjunct Faculty And ProfessorIndian Institute Of Technology, RoparStockholm County, Sweden
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Adjunct Faculty/ProfessorIndian Institute Of Technology, Ropar Dec 2023 - PresentPunjab, IndiaPassionate about bridging the realms of data science and healthcare, I bring 8+ years of experience in relevant fields like data analysis, healthcare informatics, etc. As an adjunct professor, I aim to inspire the next generation of healthcare data scientists through dynamic instruction and hands-on learning experiences.Curriculum DevelopmentData Science InstructionHealthcare AnalyticsMachine LearningStatistical AnalysisStudent MentorshipOnline Course DeliveryCourse Assessment and EvaluationIndustry Collaboration
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Co-Founder And Chief Executive OfficerInflanova Ab Sep 2021 - PresentStockholm, Stockholm County, SwedenInflanova AB is a dynamic company with a vision to address the need for improved treatment of chronic inflammatory disease through novel vaccination. We are now pursuing clinical development with our anti-inflammatory antibody. -
Associate ResearcherKarolinska Institutet Jan 2024 - PresentStockholm County, Sweden -
Postdoctoral ResearcherKarolinska Institutet Jul 2022 - Dec 2023Stockholm County, Sweden
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Doctoral CandidateKarolinska Institutet Jul 2017 - Jun 2022Stockholm, Stockholm County, SwedenTo understand the immune system which plays an important role in cardiovascular disease (CVD) and atherosclerosis, where activated immune competent cells producing cytokines are abundant for example, active and passive immunisation can influence the degree of atherosclerosis in animal experiments, but no treatment developed to specifically ameliorate inflammation is presently available. The cause of the chronic inflammation and immune activation in atherosclerosis has not been fully defined, and there are different, non-mutually exclusive and potentially synergistic possibilities including oxidised (ox) LDL and derivatives and also dead cells. Atherosclerosis in itself is in general not enough for development of CVD; rupture or erosion of atherosclerotic plaques is of major importance. To identify factors that promote plaque rupture or erosion is thus one of the major challenges of today within CVD research. We demonstrated that oxLDL can activate major immune competent cells in atherosclerosis, including B-cells T-cells, monocytes/macrophages and endothelial cells and that the phospholipid moiety (pro-inflammatory phospholipids like lysoPC; and platelet activating factor (PAF)-like phospholipids with phosphorylcholine (PC) as the main epitope) in oxLDL causes pro-inflammatory effects and immune activation (including IFN-gamma induction).
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Clinical LeadCognes Feb 2024 - Jul 2024Stockholm, Stockholm County, Sweden -
Chief Scientific OfficerValnizen Healthcare Dec 2021 - Jun 2024Mumbai, Maharashtra, India• Fulfill the company’s mission and strategic objectives by advancing assets through pre-clinical and early clinical development.• Formulate and supervise the overall research & development strategy of the company including all phases of discovery, preclinical and early clinical development.• Supervise key discovery experiments and development processes to advance company’s pipeline programs towards the envisioned preclinical and clinical development milestones.• Establish research priorities, resourcing and scientific outcomes to achieve the company’s strategic goals and objectives.• Supervise the interactions with external academic, biotech and contract research organizations (CRO), engage external research environment and establish collaborations consistent with internal strategies.• Mentor and develop direct R&D reports, oversee and supervise the company’s IP portfolio for its R&D pipeline. -
Chief Scientific OfficerElmentoz Research Feb 2023 - May 2024Bhubaneswar, Odisha, India -
Doctoral CandidateUniversiteit Maastricht Jul 2017 - May 2022NetherlandsTo understand the role of Extracellular vesicles (EVs), which are considered major players in promoting macrophage (MO) and VSMC-mediated calcification in vitro and in vivo. EVs can be produced by living cells (micro- and matrix vesicles, exosomes) and dying cells (apoptotic bodies) and are present in calcified arteries of CKD patients. VSMC can generate EVs in vitro that differ in composition and calcifying properties depending on environmental factors such as Ca2+ and phosphate, and phenotype. VSMC normally produce EVs that contain inhibitors of calcification such as carboxylated-MGP and Fetuin-A.Elevated Ca2+ and phosphate, inflammatory cytokines and reactive oxygen species can cause phenotypic switching and a shift of production towards EVs lacking inhibitors and exposing pro-calcifying phosphatidylserine (PS) and annexin A5. Little is known about other lipid moieties of EVs and their role in VC, e.g. phosphorylcholine (PC) and malone dialdehyde (MDA) although both are implicated in atherosclerosis. I will design novel EV-targeting compounds for imaging and treatment of VC. -
Managing DirectorInkruds Biotech Pvt. Ltd. Jul 2016 - Aug 2020Bhubaneswar, Orissa, IndiaWorking on developing a product called " Ripening Bio-sensorBio strip" for fruit ripening stage analysis & fruit spoilage prevention. For which received an MSME Grant from Govt. of India and GYTI BIRAC SRISTI Appreciation Award. Later took a major initiative to start something on my own, which led to the inception of our startup named “InkRUDS Biotech Pvt. Ltd.” -
ResearcherAnnexin Pharmaceuticals Ab (Publ) Nov 2018 - Mar 2019Stockholm, Stockholm County, SwedenINTRICARE Industrial Secondment- EU Project. -
Graduate Research AssistantFaculdade De Engenharia Da Universidade Do Porto Jan 2016 - Jul 2016Porto, PortugalMaster Thesis Project: The role of secondary metabolites and quorum-sensing molecules on biofilm formation by drinking water microorganisms. -
Graduate Research AssistantUniversity Of North Carolina At Chapel Hill Jun 2014 - Dec 2014United StatesWorked with Prof. Oliver Smithies (Nobel laureate for Medicine-2007) for 6 months at University of North Carolina, Chapel-Hill, USA. My research goals were more focused towards genetically engineered mouse models to investigate the role of blood pressure and diabetes regulating genes in metabolic syndrome and cardiovascular diseases using gold nanoparticles, where I have worked with kidney and heart of mouse models.
Dr. Shailesh Kumar Samal Phd Med, Phd Biochem Education Details
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Chronic Inflammatory Diseases
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Cardiovascular Medicine And Biochemistry
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Bioengineering And Biomedical Engineering
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Biotechnology -
Human/Medical Genetics
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Biotechnology
Frequently Asked Questions about Dr. Shailesh Kumar Samal Phd Med, Phd Biochem
What company does Dr. Shailesh Kumar Samal Phd Med, Phd Biochem work for?
Dr. Shailesh Kumar Samal Phd Med, Phd Biochem works for Indian Institute Of Technology, Ropar
What is Dr. Shailesh Kumar Samal Phd Med, Phd Biochem's role at the current company?
Dr. Shailesh Kumar Samal Phd Med, Phd Biochem's current role is Adjunct Faculty and Professor.
What schools did Dr. Shailesh Kumar Samal Phd Med, Phd Biochem attend?
Dr. Shailesh Kumar Samal Phd Med, Phd Biochem attended Karolinska Institutet, Universiteit Maastricht, Faculdade De Engenharia Da Universidade Do Porto, Kiit University, University Of North Carolina At Chapel Hill, Kiit University.
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