Searching New Marine Leads to Switch off the pain Sea4Us’s core activities are based on compound library generation, drug discovery and preclinical development. Sea4Us’s Drug Discovery & Development Platform allows the discovery of novel pharmaceutical drugs for several unmet clinical needs. It can be used to identify novel modulators for ion channels involved in different pathologies such as chronic pain, epilepsy, diabetes, cardiac arrhythmia, hypertension, and skin diseases, among… Show more Searching New Marine Leads to Switch off the pain Sea4Us’s core activities are based on compound library generation, drug discovery and preclinical development. Sea4Us’s Drug Discovery & Development Platform allows the discovery of novel pharmaceutical drugs for several unmet clinical needs. It can be used to identify novel modulators for ion channels involved in different pathologies such as chronic pain, epilepsy, diabetes, cardiac arrhythmia, hypertension, and skin diseases, among others.sea4us.pt Show less

In Marcel Jaspers research groupUnder the scientists mobility program H2020-MSCA-RISE: Ocean Medicine Analytic chemistry using NMR; ESI-MS-HPLC; HPLC

In Jeanette H. Andersen research groupUnder the scientists mobility program from H2020-MSCA-RISE: Ocean Medicine

In Donatella De Pascale research groupUnder the scientists mobility program from H2020-MSCA-RISE: Ocean Medicine

The aim of the project was to evaluate if marine natural extracts could be proposed as new cellular therapy (natural alternative) for chronic lymphocytic leukemia patients. Both leukemia cell lines (K562 and BV-173) and normal blood cell lines (PBMCs) were addressed.

Search of marine natural compounds- Testing marine extracts from Azores deep sea animals as anticancer, antimalarial and antibacterians

SFRH / BD / 72154 / 2010 - Project "Bioprospecting deep-sea marine animal fatty acids from the Azores for possible therapeutic applications"

Fatty acid and sterol identification from deep-sea invertebrates by GC-MS. Advanced analytical techniques as LC-ESI-MS to achieve better separation of lipid components from complex bioactive marine extracts. https://www.marum.de/en/HinrichsLab_Guests.html

Bioassays of extracts against commercial cancer cell lines and Methicillin-Resistant Staphylococcus aureus cultures for the search of new marine natural compounds as anticancer and antibiotics.

Project CHEMECO: Monitoring Clonisation in Chemosynthetic Ecosystems. Main activities were lipid extraction and fatty acid analyses in gas-chromatographer (GC) for the comparative study of trophic structure and colonization processes of different substrates in Atlantic hydrothermal vents and Mediterranean mud volcanoes.

Project CIMBA-Development and Implementation of a regional, national and International net for oceanographic monitoring (hydrodynamic and biologic) in the Azores Archipelago. Scientific crew member in oceanographic research vessel “Arquipelago”: responsible for water sample collections (Rosette) for biological analyses and other in situ analyses (CTD). Cruise logistics and operations. Preparation of cruise reports. Field and laboratory equipment maintenance. Microbial plankton analyses based… Show more Project CIMBA-Development and Implementation of a regional, national and International net for oceanographic monitoring (hydrodynamic and biologic) in the Azores Archipelago. Scientific crew member in oceanographic research vessel “Arquipelago”: responsible for water sample collections (Rosette) for biological analyses and other in situ analyses (CTD). Cruise logistics and operations. Preparation of cruise reports. Field and laboratory equipment maintenance. Microbial plankton analyses based on DNA. Show less

Project OPALINA - Ocean Dynamics and related Productivity of the Northeast Subtropical AtLantIc Near the Azores region using ENVISAT, ERS, SeaWiFS, NOAA, and in situ data. Scientific crew member in oceanographic research vessel “Arquipelago”: responsible for water sample collections (Rosette) for biological analyses and other in situ analyses (CTD). Cruise logistics and operations. Preparation of cruise reports. Field and laboratory equipment maintenance.

Laboratory organization and equipment maintenance. Use of molecular biology techniques for animal and vegetal species identification or genes. DNA extractions, PCRs, electrophoresis in agarose gels and sample preparation for sequencing.Coordination of laboratory activities and assistance of students. Management of laboratory materials and reagents. Management of satellite images and maintenance of AVHRR station.

Main activities: primers optimisation, PCRs and electrophoreses in agarose gels. Result analyzes using Arlequim and Dispan. Preparation of scientific posters presented in International Conferences and scientific paper published in the International Journal “American Journal of Human Biology”.

Collaborator in several scientific projects ongoing in the Molecular Biology Research: Sequencing of Trachurus picturatus D-Loop fragment from different locations in the North Atlantic Sea for management purposes (fish stocks); Fish identification for species with high commercial value using PCR-SSCP technique (PCR- Single Strand Conformational Polymorphism) on fisheries products (fraud detection)

Laboratory Technician in the Environmental Control laboratory.Several chemical analytic analyses using High Performance Liquid Chromatography (HPLC) and Gas Chromatographer (GC)