Sofia Caruso Email & Phone Number

Tarrytown, New York, Us

Explore novel antibody-enzyme conjugate therapies for central nervous system and target organ delivery and pain phenotype correction in lysosomal storage disease (LSD). • Independently developed protocols for LSD mouse models, downstream enzymatic activity, and neuron-specific immunofluorescence staining to assess biodistribution and internalization of enzyme delivery in brain and peripheral mouse tissues.• Participated in an internal company Poster Day that aimed to allow colleagues from different departments to gain insight on other groups’ projects.Investigated the therapeutic potential of retargeted antibodies for delivery and internalization of lysosomal enzymes in the brain of Pompe Disease (PD) mouse models.• Designed several experiments to validate blood brain barrier crossing of retargeted antibodies both in in vitro and PD mouse models.• Presented to department leadership to discuss opportunities for applying findings to therapeutics lacking blood-brain barrier-crossing capabilities. • Attended WORLD Symposium conference on lysosomal storage diseases.Investigated effects of immunomodulatory antibody functionality on anti-drug antibody (ADA) generation in PD mouse models, using direct ELISAs, to assess potential to redose novel ERT.

Tarrytown, New York, Us

Tarrytown, New York, Us

Former member of the Regeneron Campus Ambassador Program. I help organize and attend Regeneron led events to inform undergraduate students and others about the company, for internship and full-time recruitment.

Tarrytown, New York, Us

Conducting virology research in the Viral Development Technologies department at Regeneron under Chun Wai Yip. Explored retargeting strategies for viral delivery of therapeutics using novel conjugated viral envelopes. Presented to departmental team leaders about novel retargeting strategy, platform protocols, and useful applications discovered in literature analysis.

Assisted the student led comedy troupe "The Lilting Banshees" as stage manager for three shows. Helped organize, design, and control lighting and sound for each performance. Offered directions and feedback during tech rehearsals. Worked alongside the troupe to bring their creative ideas to life through the use of music and lighting.

Winston-Salem, North Carolina, Us

Worked under Dr. Ravi Singh on developing silver nano particle technology aimed at inducing lipid peroxidation for anti-cancer therapeutics. Investigated the immunotherapeutic potential of silver nanoparticles in non-small cell lung (SKLU1) cancer cells by assessing cell viability, measuring lipid peroxides and degradation products, and observing changes caused by fibronectin knock down.

I was a member of the non-profit organization HOSA on Wake Forest University's campus. I participated in 2 service events pertaining to the science education of children and mentoring for pre-medical school students.

I was a standards representative for the Sigma Chapter of Kappa Beta Gamma sorority. I helped ensure all sorority activities are done safely and abide by the sorority and University Greek Life bylaws. I assisted the Standards Head in resolving issues that arise.

Active member of the Sigma Chapter of Kappa Beta Gamma International Sorority.

Winston-Salem, Nc, Us

Earned a Bachelor’s of Science degree in Biology, with minors in Chemistry and Creative Writing. A part of the sorority Kappa Beta Gamma and worked in an undergraduate research lab for Cancer Biology. Graduated Cum Laude.

Winston-Salem, North Carolina, Us

I worked in Dr. Ulrich Bierbach's Medicinal Chemistry lab, for 4 semesters. I was tasked with performing cell culture work on various cancer cell lines (primarily A549), testing drugs and other compounds on the cells to see which treatment is the most efficient. I characterized the stability and inhibitory potential of novel platinum-based therapeutics on lung and breast cancer cell viability, as higher-sensitivity alternatives to standard-of-care therapies. I co-authored a paper on this work that was published in July of 2020.

Winston-Salem, Nc, Us

Debate and assist with research on cases for the Wake Forest Ethics Debate Team.

Tarrytown, New York, Us

Interned under Don Yeung and worked on a project focusing on developing and implementing controlled documents outlining the processes the CDSL group was involved in. Ended up creating 6 documents that created a more organized workspace and provided a template for other members of the team to utilize in creating future controlled documents.

I have written 4 articles for the online magazine WFU Style. These articles focus on a wide array of topics (e.g. Album Reviews, Fashion Trends, Stress Management, Pop Culture). Furthermore, I have done a takeover of the blog's Instagram story.

I am on the video editing committee for Wake N Shake. Wake ‘N Shake is an annual fundraiser held on campus to support the Brian Piccolo Cancer Research Fund. As a member of the video editing committee, I will be participating in all 12 hours of the fundraiser, taking videos and photos of the event. I also will help with creating a video for the organization's 15th anniversary, describing their history and development over the years.

Tarrytown, New York, Us

I was a Clinical Drug Supply and Logistics intern for 11 weeks. I created a Distribution Cost Comparison template, that provided my team with a more accurate and efficient method of comparing study quotes from various vendors. Additionally, I worked on the "What is a Clinical Study?" project, that condensed the process and roles within a clinical study onto one graphic, and demonstrated the process differences in various therapeutic areas.

Wake ‘N Shake is an annual fundraiser held on campus to support the Brian Piccolo Cancer Research Fund. I assisted in creating posters and helping students sign up for the event. In total, we raised $412,669.48 for the Brian Piccolo Cancer Research Fund.

Vancouver, British Columbia, Ca

New Haven, Ct, Us

I worked for two summers with mentors Wesley Cai and Jocelyn Chen. My first summer project focused on designing and cloning short hairpin RNAs (shRNA) targeting certain epigenetic proteins and identifying which hairpin produces the best knockdown efficiency of the target genes. I performed experiments involving protein assays, PCR, molecular cloning, cell culture, and in vivo metastasis. My second summer, I worked on my own project, where I successfully generated CRISPR knockout cell lines, which were used to study the functions of an epigenetic regulator for breast cancer metastasis.

Tarrytown, New York, Us

I worked alongside Asma Parveen in the Oncology research department, at Regeneron Pharmaceuticals. I helped Asma with her project, by working on changing media, growing cells, analyzing the ratio of live cells to dead cells, etcetera.

Read and choose essays and artwork for student literary magazine;edit essays, won a Columbia Press Gold Medal for work in the 2018 edition

Greenwich, Connecticut, Us

Biology Major | Chemistry & Creative Writing Minor, Biology/Biological Sciences, General

High School Diploma