Stephen Abbott Email & Phone Number

Cambridge, Ma

Waltham, Ma

• Responsible for development of study proposals and execution of in-vivo tolerability, PD/PK, efficacy, modeling studies, animal ordering, injections (sc, ip, iv, id), tissue/blood collection for analysis, measurements, data compilation, presentation and interpretation• Assist with cell culture harvesting, scale-ups for mammalian cell lines to be dosed in-vitro• Provide guidance, data updates, recommendations, and future study proposals as a Pharmacology project team lead

Cambridge, Massachusetts

• Study Director for all aspects of in-life experiments (Protocol creation, animal ordering, cell culture, injections, measurements, data compilation, presentation and interpretation)• Develop more efficient operating procedures to coincide with rapid company growth and a larger study output demand• Technical training and development of new and junior associates• Routine culture and maintenance of cell lines for various mouse tumor models• Establish xenogeneic mouse tumor models and murine stem cell engraftment models• Routine injections (sc, ip, iv, id), measurement of tumors, necropsy, blood and tissue collection for in vitro assays, monitoring of animal health, mouse handling, etc.• Assist with establishment of new animal models as needed, including running pilot studies for model development and trouble-shooting

Lexington, Ma

• Liaise outsourced studies through CROs, and prepare and review scope of work documentation• Assist with development and characterization of complex disease models to evaluate therapeutic efficacy of drug candidates• Contribute to the discovery and validation of new target opportunities for drug development• Perform specialized in-vivo imaging techniques to accelerate development timelines and improve clinical translatability• Assist with the creation of protocols, study designs, and SOP documents• Processing, compilation, and reporting of data/study results to scientific staff• Coordinate internal and external colony maintenance responsibilities• Execute in-vivo studies to explore mechanisms of action and PK/PD relationships of compounds• Routinely perform in vitro/ex vivo assays (ELISA, PCR, histology)

Lexington, Ma

• Provide advanced technical support for Principal Investigators to ongoing research programs (imaging, dose administration, necropsies, blood collection/processing, tissue harvests, assays)• Manage procurement of laboratory supplies within the research facility• Supervise and train lab technicians on study procedures and technical work• Manage all in-house animal colonies - ordering, census database, weaning, identification, biopsies, and shipments to CROs• Ensure compliance of regulations and guidelines for company policies and practices onanimal care and research security (GLP, USDA, AWA, OSHA, IACUC)• Review and implement new SOPs to coincide with facility requirements• ALAT Certified (Assistant Laboratory Animal Technician)

• Maintain all project breeding colonies - genotyping, biopsies, weanings, and census reporting• Primary technical support to the scientific staff• Perform animal husbandry duties including cage changing, observation, treatment, vivarium maintenance and general housekeeping per Standard Operating Procedures• Monitor and manage the procurement of facility supplies

Sitka, Alaska

• Assist Veterinarian with clinic procedures (blood drawing, physical examinations, anesthesia, euthanasia, x-ray imaging, animal restraint, behavior observation and recording)• Manage animal husbandry staff and volunteers• Social media development specialist• Train and handle new raptors for residence at the center• Deliver formal education programs for a variety of audiences (pre-school through adults)• Perform animal husbandry duties (sanitizing enclosures, building new habitats, preparing diets)

Los Angeles,

• Oversight of the breeding colonies• Maintain census, data logs, and spreadsheets• Promptly complete Animal Release Requests for laboratory PI• Collaborate with fellow colleagues to ensure completion of daily tasks• Evaluate animal health, report abnormal conditions, monitor and provide treatments as directed

• Oversight of the in-house breeding colonies and genotyping services• Document, organize, and maintain timely records for activities• Provide guidance and training to less experienced staff and student interns• Quality Assurance primary for the vivarium equipment calibration program• Evaluate animal health, report abnormal conditions, monitor and provide clinical treatments • Complete animal husbandry and support services according to SOPs