Steve Wu Email & Phone Number

United States

1. Lead cross-functional teams on endometriosis preclinical efforts2. Support ovarian cancer preclinical research3. Provide guidance on reproductive health research projects

Lausanne, Vaud, Switzerland

Research Triangle Park, North Carolina, Usa

Major scientific achievements: Revealed the hormone dependent molecular mechanisms that structurally and functionally remodel uterine muscle during pregnancy.The Staff Scientist in the National Institute of Health is equivalent to the rank of assistant professor in US universities. My responsibilities include: 1, Direct and manage operations among research staff, CROs and in-house Core labs to conduct research projects in the fields of early pregnancy failure, preterm birth, post parturition tissue regeneration, leiomyoma and ovarian and endometrial cancer. 2. Compose, maintain and edit project proposals, compliance documents, progress reports, scientific manuscripts and technical notes. 3. Design and create novel reagents for preclinical research, including genetically engineered mouse and CRISPR technology modified cell models. 4. Interpret large genomic, epigenomic and proteomic data from NextGen sequencing and mass spec studies to identify novel biomarkers.5. Serve as a scientific mentor for research team members. 6. Provide consultations on research projects of my team and to those of other research groups.

Major scientific achievement: Identified a novel hormone modifier gene that controls intercellular communication in the uterus.Work as an acting Staff Scientist on the track of merit promotion

Major scientific achievement: identified and functionally characterized the NR2F2 gene as a biomarker and a driver for dilated cardiomyopathy.

Major scientific achievement: Identified NR2F2 as the molecular switch that determines the cardiomyocyte’s chamber identity. Made 20 genetically engineered mouse alleles for preclinical study of hormone receptors in cancer and heart failure.Project 1: Construct a genetic tool set for the National Institute of Health by engineering embryonic stem cells and produce diseases models in animals to facilitate the research on diabetics, cancer, heart failure, and reproductive diseases. (http://www.nursa.org/)Project 2: Investigate the underlying molecular mechanisms for tissue regeneration and disease causes in hearts and female reproductive systems. Using COUP-TFII mutant mice as the model to explore regulatory programs of cardiac and uterine development/pathogenesis that may serve as potential intervention targets for regenerative medicine.

Studied the role of Tbx18 gene in mouse development. Designed and engineered mice with a mutation in the Tbx18 gene. The mutant mice served as disease models for studying the causes of congenial heart diseases, coronary artery defects, bone regeneration, and kidney diseases.

Developing a novel surgical strategy to enhance nerve regeneration for repairing injured spinal cords. Coordinated the clinical trial application for this surgical treatment on patients. Participated in establishing a rat model of repairing spinal cord injury through surgical intervention and growth factor stimulation. The work since then has been helping many patients to regain motion capabilities after trauma caused paralysis.

Taiwan

Studied the light-regulatory system in plant photosynthesis genes. Being the first to clone the regulatory region of the gene that produces an indispensible component for spinach to perform photosynthesis. Also purified a protein that binds to this regulatory region that may participate in gene regulation. The results laid the groundwork for enhancing agricultural production in the future.

Doctor Of Philosophy (Phd), Cardiovascular Sciences

Visiting Scholar, Cardiovascular Science

Master Of Science (M.S.), Biochemistry

Bachelor Of Science (B.S.), Agricultural Chemistry