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Experienced preclinical researcher in pharmaceutical drug discovery. Expertise in high throughput screening, compound profiling (SAR) and assay development for GPCR, enzyme and protein:protein targets. Experienced and successful program leader for both GPCR and epigenetic targets with a record of delivering lead compounds for further developmentSpecialties: High Throughput Screening (HTS), Structure Activity Relationship (SAR), biochemical assay development, data analysis, project leadership for discovery stage projects, Developability and Safety Screening
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Vice PresidentGsk Nov 2015 - PresentStevenage, United KingdomI current lead a worldwide group, Protein Cellular and Structural Sciences that supports discovery activities across all of GSK’s therapeutic modalities. The group has two key remits:1. Design, generate and validate biological reagents to support both biopharm and small molecule discovery platforms. The group has expertise in broad range techniques for reagent generation, including molecular biology, protein expression, scale up, cell line development, genome editing, stem cells and primary cells. 2. Provide structural and mechanistic understanding of drug target, molecular recognition and mode of action to drive selection of the best molecules. Group expertise includes, crystallography, cryo-EM and a broad range of biophysical techniques (e.g. SPR, NMR, HDX-MS). -
Director, Biological Science UkGsk Oct 2013 - Nov 2015Stevenage, United KingdomI currently lead a department of discovery scientists whose remit includes, biological reagent design and generation, assay development, screening for hit identification, compound profiling (SAR), mechanism of action studies and developability screening. The department utilises a broad range of technologies and skills sets to support the disease focussed business partners, including primary cell handling expertise, phenotypic screening, high content imaging, flow cytometry, functional ion channel screening, biophysics (high throughput SPR and Mass Spec) as well as an array of more conventional fluorescent screening techniques.
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Mdr Portfolio Progression Head, StevenageGsk May 2013 - Nov 2015Stevenage, United Kingdom
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Director, Screening And Compound Profiling UkGlaxosmithkline May 2011 - Oct 2013Stevenage, United KingdomResponsible for a department of 40 scientists, supporting local therapy area groups. Department provides screening activities through provision of focussed screening and fragment screening for the identification of new chemical starting points as well as compound profiling activities to support lead optimisation chemistry. Department has a key expertise in utilising phenotypic screening approaches and developability screening.
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Section Head, Screening And Compound Profiling UkGlaxosmithkline Jan 2009 - May 2011I managed a group of 10-12 scientists with the remit of performing compound profiling (SAR) of focussed screening for enzyme and GPCR targets in support immuno-inflammatory, cardiovascular and respiratory disease areas. I built an empowered, flexible and highly motivated organisation capable of meeting business needs. I demonstrated a track record of developing strong links with other business groups to evaluate and establish biophysical screening techniques as core technologies for routine SAR screening.
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Team Leader, Screening And Compound ProflingGlaxosmithkline Jul 2006 - Dec 2008Responsibile for a team of 4-6 scientists with a remit for assay optimisation and execution of high throughput screens in miniaturised functional assay formats for GPCR, enzyme, kinase, nuclear receptor, transporter targets. Received an exceptional award for program leadership of a family GPCR C antagonist program.
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Principal Scientist, Screening And Compound ProflingGlaxosmithkline Jan 2005 - Jun 2006Managed a team of 3 people carrying out assay development, HTS and SAR for GPCR and enzyme targets.
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Senior Scientist, Molecular ScreeningGlaxosmithkline Jan 2001 - Dec 2004Responsible for development and execution of high through put screens. Received exceptional science award for the key role played in the evaluation and implementation of imaging plate readers.
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Scientist, Lead DiscoveryGlaxosmithkline Jan 1998 - Dec 2000Involved in the evaluation and integration of early 1536 dispensing and plate reading technology within the Advanced Technology Group of Lead Discovery.
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Scientist, BioprocessingGlaxosmithkline Oct 1996 - Dec 1997Part of fungal strain improvement programme, using site directed mutagenesis, HPLC and large scale fermentation techniques to improve titre of key development compound.
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DirectorElrig (European Laboratory Robotics Interest Group) Aug 2010 - PresentI am a board member and Director of the European Laboratory Robotics Interest Group (ELRIG). I served in the roles of Treasurer and Company Secretary for 3 years.
Stuart Baddeley Skills
Stuart Baddeley Education Details
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Applied Biology
Frequently Asked Questions about Stuart Baddeley
What company does Stuart Baddeley work for?
Stuart Baddeley works for Gsk
What is Stuart Baddeley's role at the current company?
Stuart Baddeley's current role is VP, Protein Cellular and Structural Sciences.
What is Stuart Baddeley's email address?
Stuart Baddeley's email address is st****@****gsk.com
What schools did Stuart Baddeley attend?
Stuart Baddeley attended University Of The West Of England.
What skills is Stuart Baddeley known for?
Stuart Baddeley has skills like Drug Discovery, High Throughput Screening, Assay Development, Pharmaceutical Industry, Life Sciences, Biotechnology, Protein Chemistry, Biochemistry, Gpcrs, Pharmacology, Hplc, Clinical Development.
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