Sujoy Mukherjee Email & Phone Number

Kolkata Area, India

Serotonin GPCRs in Mental Health diseases• High yield over-expression of GPCRs in Sf9 cultures using baculoviral expression system (Ref. Mozumder et. al. . Bio-protocol, 2020, 10, e3704.)• Modulation of oligomeric states of Serotonin G-protein coupled receptors by cholesterol: a Cyro-electron Microscopic study – Expression, purification of GPCRs using baculoviral expression system (Ref. Mahesh et. al. Protein Pept. Lett. 2018, 25, 390 - 397)Solution NMR and Molecular Dynamics simulations• Tuning of Conformational Entropy in hot-spot cancer mutants of p53 DNA binding domain by Solution NMR and atomistic Molecular Dynamics simulations (Ref. Bej et. al. Biochemistry, 2018, 57, 6265 – 6269, and Rasquinha et. al. Biochemistry 2017, 56, 4962 - 4971) • Reshaping thermodynamic and kinetic energy barriers in Transthyretin amyloidosis: Role of transiently formed “invisible” states of proteins (Ref. Das et. al. Angew. Chem. Int. Ed. 2014, 53, 12781-12784.

Columbus, Ohio Area

• Conformational dynamics of human Immunoglobulin light chain domains: Implications for protein misfolding and amyloid formation in AL amyloidosis (Ref. Mukherjee et. al. Biochemistry 2011, 50, 5845-5857 and Mukherjee et. al. Sci. Rep. 2017, 7, Article Number 10339)

Urbana-Champaign, Illinois Area

PhD Thesis title – Applications of Solid-state NMR spectroscopy as a tool for structure based drug design• Solid-state Magic-angle NMR and Calorimetric studies on the interactions of osteoporosis drugs with human bone: Investigations into the structure, dynamics and multiple binding sites (Ref. Mukherjee et. al. J. Am. Chem. Soc. 2009, 131, 8374-8375 and Mukherjee et. al. J. Am. Chem. Soc. 2008, 130, 1264-1273)• Design of lipophilic bisphosphonate inhibitors of isoprene diphosphate synthase enzymes by NMR (Ref. Mao et. al. J. Am. Chem. Soc. 2006, 128, (45), 14485-14497 and Zhang et. al. J. Am. Chem. Soc. 2009, 131, (14), 5153–5162)• Quadrupolar couplings and chemical shift measurements of 67Zn by Solid-state NMR (Ref. Mukherjee et. al. J. Am. Chem. Soc. 2005, 127, (8), 2370-2371)• Design and construction of NMR spectrometers and static probes - Home-built 500 MHz solid-state NMR for measurement of 67Zn chemical shifts and EFGs, Probe design (static probe) for measurement of 2H line-shapes.

Phd, Biophysics And Computational Biology

Postdoctoral Research, Biophysics And Chemistry

B-Tech, Biotechnology And Biochemical Engg

High School

Education record