Sushil Kumar Email & Phone Number

Glen Mills, Pa, Us

Newark Delaware

Nebraska

• In-vivo PK of discovery compounds (bioavailability, tissue distribution) in rodents.• Drug-drug interaction and lymphatic bioavailability study of anti-HIV combination in rodents.• PK modelling by non-compartment analysis and compartment modelling (Phoenix Winnonlin).• In-vitro ADME including metabolic stability (microsomes, S9), CYP inhibition, reaction phenotyping and plasma protein binding assays for IND-enabling discovery compounds.• CaCO2 permeability assay validation for screening discovery compounds.• Development/validation of LC-MS/MS-based bioanalytical methods for PK studies.• Biotransformation pathway identification using LC-MS/MS based metabolite id.

Toronto, Canada Area

Literature review, protocol preparation and research planning.

Toronto, Canada Area

• Development/validation of analytical methods for analysis of drugs and metabolites in plasma.• Routine analysis of plasma samples for bioavailability and bioequivalence studies.• Preparation of bioanalytical protocols.

Toronto, Canada Area

• Preclinical testing of novel therapies targeting CNS tumors in mice.• Elucidating the mechanism of action of drugs.• Assisting Principal Investigator with clinical trial protocol preparation.

Toronto, Canada Area

• Preclinical evaluation of novel anticancer therapies in mice models of pediatric solid tumors.• Prediction of Human Equivalent Dose (HED) based on preclinical efficacy and safety.• Evaluation of markers of efficacy, toxicity and resistance of anticancer drugs.• Bioanalysis/Pharmacokinetics of anticancer drugs in plasma by HPLC and LC/MS.• Interaction with industry staffs as part of research collaboration.• Preparation of manuscripts for publications and presentation at scientific conferences.

Toronto, Canada Area

• Development and validation of analytical methods (solid-phase extraction, liquid-liquid extraction, protein precipitation) for the analysis of drugs and metabolites for bioavailability and bioequivalence studies.• Procurement, storage and retrieval of biological samples for analysis. • Preparation of STPs and protocols for routine bioanalysis.• Archiving raw data and final report in proper manner for easy traceability and integrity.

• Assessment of ADME of lead compounds for IND-enabling projects for metabolic ailments.• Development/validation of methods for preclinical DMPK (PK/TK) using HPLC and LC/MS. • Preparation of SOPs, STPs and protocols related to instruments, procedures and activities.• Performance check/calibration of laboratory instruments.

Dewas Area, India

• Analysis of pharmaceutical dosage forms and raw materials at various manufacturing stages using HPLC: Assay, Related Compounds, Dissolution Testing.• Development and Validation of analytical methods for pharmaceuticals.• Calibration of instruments like HPLC and Dissolution Apparatus as per FDA guidelines.

Doctor Of Philosophy (Phd), Anticancer Pharmacology

Thesis: Preclinical Evaluation of Oral Metronomic Topotecan and Pazopanib for the Treatment of Aggressive Extracranial Pediatric Solid.

M.Pharm, Pharmaceutical Sciences

B.Pharm, Pharmaceutical Sciences

Education record

Education record