Genomic Medicine UnitTranslational Cluster, Ophthalmology Research, Target ID• Project head for preclinical gene therapy program; manages internal and external (CRO) studies to meet timelines; presents preclinical package at governance meetings; prepares study reports and other documentation necessary for patent filings, clinical protocol development, and regulatory (IND) filings• Directs new target ID and validation efforts for ophthalmology; leads multi-disciplinary collaboration to establish and implement genomics-based computational and experimental approaches to identify genetically validated targets for prioritized indications• Leads team of direct reports responsible for designing and executing target ID and validation studies; developing in vitro and in vivo disease models; developing and optimizing molecular, cellular, and biochemical assays; assessing metabolic, inflammatory, degenerative, and other disease-relevant phenotypes in cell and animal models; designing and testing gene therapy candidates; and conducting preclinical studies to establish delivery, pharmacology, tolerability, and efficacy of gene therapy candidates• Collaborates with research teams across therapeutic areas and research platforms, and with colleagues across functional areas, including CMC, preclinical safety, translational medicine, regulatory, legal, and clinical development, to prepare an IND-enabling package and advance programs towards patients

I serve in an institutional leadership position that is involved in shaping institutional directions and decisions, and holds responsibility for supporting the Broad community through service roles

Diabetes Research GroupPrograms in Metabolism & Medical and Population GeneticsI lead a research team responsible for determining the disease mechanisms of metabolic disease-associated genetic variants and effector genes in order to identify and validate new therapeutic targets and biomarkers of effect. I work closely with the director of diabetes research and other colleagues to establish, develop, and implement research strategy and collaborative research plans for a diverse team of computational biologists, molecular and cellular biologists, chemical biologists, and clinicians that spans Boston-areas research institutionsMember, Retreat Committee (2018-2022)Fellow, Broad Research Communications Lab (2016-2022)Mentor, Broad Mentoring Program (2017-2018)Member, Institutional Animal Use and Care Committee (2014-2020)Member, Staff Scientist Development Committee (2011-2016)Environmental Health and Safety Representative (2010-2014)

Diabetes Research GroupPrograms in Metabolism & Medical and Population Genetics

Laboratory of David AltshulerProgram in Medical and Population Genetics

Laboratory of David AltshulerProgram in Medical and Population Genetics

Diabetes Unit (2015-2022)Analytical and Translational Genetics Unit (2010-2015)Center for Human Genetic Research/Center for Genomic Medicine (2010-2022)

Laboratory of Dr. Laura AttardiDepartment of Radiation OncologyStudied the role of the pro-apoptotic gene Siva in DNA-damage induced, p53-dependent apoptosis.Developed and characterized a Siva-knockout mouse model.

Laboratory of Dr. Laura AttardiDepartment of Radiation OncologyStudied the role of the pro-apoptotic gene Siva in DNA-damage induced, p53-dependent apoptosis.Developed and characterized a Siva-knockout mouse model.

Laboratory of Dr. Pamela MellonDepartment of Reproductive MedicineBiomedical Sciences Graduate ProgramDefined regulatory elements and transcription factors involved in gonadotrope-specific transcriptional regulation of the LH and FSH beta-subunit genes.