Jeong Ho Kim Email & Phone Number

San Diego, California, United States

San Diego

• Design and develop new assays to examine new drug application and efficacy for spinal discregeneration
• Examine of product material on nucleus pulposus cells for spinal disc repair under hypoxicconditions and 3D culture
• Preclinical rabbit study design and discussion for spinal disc regeneration
• Preparation of product material for cartilage regeneration in GMP environment
• Preparation CMC documents and FDA IND filing
• Cooperate and work with CROs & Tech transfer to CROs

San Diego, California, United States

• Collagen based and hECM derived dermal filler preparation in GMP environment and performing CofA tests for product
• Develop a new material preparation method to improve the effect of material
• Write SOPs and assay developmental reports
• Preparation documents for pre-clinical studies and FDA IDE filing
• Examine the effect of ECM-AMP (antimicrobial peptide) on rabbit wound healing model(Collaborated with Marsha Rolle Lab in Worcester Polytechnic Institute(WPI))

La Jolla, California

• Develop and examine melanoma cell model to test Xycrobe strains effect on melanoma progression and metastasis
• Develop new in-cell detection screening methods to screen out anti-inflammatory effect of multiple bacteria strains
• Attend meetings and seminars by venture capitals and present data to investors
• Write and review Small Business Innovation Research (SBIR) grants
• Work with external vendors and decide new instruments for company
• Work as safety officer to be responsible for all safety issues such as chemicals inventory, hazardous wastes etc. and prepare for Environment, Health, and Safety (EHS) audit

La Jolla

• Establish and examine anti-inflammatory effect of Xycrobe strains (Propionibacterium acnes) in vitro
• Design and develop psoriasis mouse model and examine Xycrobe strains by topically application on mouse skin
• Develop new experimental procedure for human skin biopsy in trans-well culture
• Measure cytokine proteins secreted by genetically engineered bacteria and examine downstream signaling molecule activation
• Isolate CD4 T cells from healthy and acne patient blood by MACS cell separation and analyze gene expression profiles by RNA-seq
• Write reports for collaborators and present data at conferences

• Generate CRTC2/CRTC3 combination KO mice and characterized CRTC2/3 double KO mice at the different embryonic stages
• Discover splenomegaly and neutrophilia phenotypes of CRTC2/3 combination KO mice and characterize this mouse by establishing new techniques in the lab such as bone marrow transplantation (BMT), blood / bone marrow.
• Analyze hematopoietic stem cells (HSC) population in bone marrow by multi-colors flow cytometry comparing WT and CRTCs KO mice
• Discover novel function of CRTCs in bone marrow to regulate hematopoietic stem cell differentiation by modulating cytokine expression in stromal cells by cytokine screening, ELISA and flow cytometry
• Examine CRTCs function in acute and chronic myeloid/lymphocytic leukemia
• Establish and characterize mouse bone marrow derived macrophages and stromal cells. Analyze the cells to investigate CRTCs functions by introducing siRNA or overexpression vector through electroporation and lenti- or.

Urbana-Champaign, Illinois Area

• Explore involvement of mTOR in nutrient overload and IL-6-induced insulin resistance in hepatocytes and discover a transcription factor, STAT3 as a novel mediator of nutrient and inflammation signals and identify a.
• Discover FOXO1 to mTOR connection as regulatory loop to modulate IGF-II expression at the transcription level by degradating mTOR complex components, that in turn inhibits skeletal myogenesis
• Examine mTOR expression and activity in different breast cancer cell lines and melanoma cell lines to see how mTOR contributes cancerous characteristics of cells
• Identify 3 novel leucine rich mTOR nuclear export signal (NES) by systematic scan of mTOR sequence. Test by using reporter system which is composed of two elements; one with NES-FRB domain of mTOR and the other with.