Thomas Bonacci

Thomas Bonacci Email and Phone Number

Research assistant professor @ University of North Carolina at Chapel Hill
Chapel Hill, NC, US
Thomas Bonacci's Location
Chapel Hill, North Carolina, United States, United States
Thomas Bonacci's Contact Details

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About Thomas Bonacci

I am a postdoctoral fellow at UNC Chapel Hill. I gained expertise in proteomics, molecular biology and protein biochemistry during my PhD which focused on how pancreatic cancer cells adapt and survive to chemotherapeutic drug treatment. During my postdoctoral training, I deepened my knowledge of cell proliferation by studying the regulation of cell division by the ubiquitin-proteasome system, with an emphasis on deubiquitinating enzymes (DUBs). My current research interest is to understand (i) the role of DUBs in cell cycle control and (ii) how they are regulated by post-translational modifications, by using computational analysis of publicly available multiomics data.

Thomas Bonacci's Current Company Details
University of North Carolina at Chapel Hill

University Of North Carolina At Chapel Hill

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Research assistant professor
Chapel Hill, NC, US
Website:
northcarolina.edu
Thomas Bonacci Work Experience Details
  • University Of North Carolina At Chapel Hill
    Research Assistant Professor
    University Of North Carolina At Chapel Hill
    Chapel Hill, Nc, Us
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  • University Of North Carolina At Chapel Hill
    Research Assistant Professor
    University Of North Carolina At Chapel Hill Jul 2021 - Present
    Chapel Hill, Caroline Du Nord, États-Unis
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  • University Of North Carolina At Chapel Hill
    Post-Doctoral Research Associate
    University Of North Carolina At Chapel Hill Apr 2015 - Jun 2021
    Chapel Hill, Nc
    ● Discovered that Cezanne/OTUD7B is a cell cycle regulated and K11 linkage-specific DUB required for mitotic progression.● Utilized biochemistry techniques (protein-protein interactions assays, in vitro ubiquitination and DUB assays, protein degradation assays) to show that Cezanne antagonizes the activity of APC/C, a key regulator of cell cycle progression.● Established in vivo ubiquitination assays routinely used in the lab.
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  • Inserm U1068, Crcm
    Post-Doctoral Inserm Fellow
    Inserm U1068, Crcm Apr 2013 - Oct 2014
    Région De Marseille, France
    ● Discovered that the activity of NUB1, a protein belonging to the p53 network, is regulated by Mdm2-mediated non-proteolytic ubiquitination. ● Developed a tandem affinity purification strategy, followed by trypsin digestion and mass spectrometry, to identify lysine 159 as the residue ubiquitinated by Mdm2.
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  • Inserm U1068, Cancer Research Center Of Marseille (Crcm)
    Phd Student
    Inserm U1068, Cancer Research Center Of Marseille (Crcm) Jan 2010 - Mar 2013
    Région De Marseille, France
    ● Developed a label free proteomic strategy to identify changes in post-translational modifications by ubiquitin, Nedd8 and SUMO1 in response to a chemotherapeutic drug in pancreatic cancer cells.● Discovered that SNIP1 SUMOylation contributes to the resistance of pancreatic cancer cells to drug treatment.● Discovered that SUMOylation of TP53INP1 at lysine 113 is necessary for its pro-apoptotic function following oxidative stress.
  • Inserm U911, Center For Research In Oncobiology And Oncopharmacology
    Undergraduate Student
    Inserm U911, Center For Research In Oncobiology And Oncopharmacology Feb 2009 - Jun 2009
    Région De Marseille, France
    ● Studied the impact of purinergic receptors P2Y on the pro-migratory signaling induced by EGF receptors.
  • Inserm U624, Stress Cell
    Undergraduate Student
    Inserm U624, Stress Cell Sep 2008 - Jan 2009
    Région De Marseille, France
    ● Studied ArgBP2 interaction with NUB1, zyxin and vimentin.
  • Cnrs U2737, Cytoskeleton And Integration Of Signals From The Tumoral Microenvironnement
    Undergraduate Student
    Cnrs U2737, Cytoskeleton And Integration Of Signals From The Tumoral Microenvironnement Apr 2008 - Jun 2008
    Région De Marseille, France
    ● Utilized an siRNA approach to inhibit the purinergic receptor P2Y2 in human epidermal cells (HaCat)

Thomas Bonacci Skills

Science Biochemistry Cell Biology Molecular Biology Culture De Cellules Ubiquitin Like Proteins Qpcr Biochimie Mass Spectrometry Sciences De La Vie Biotechnology Anticorps Fluorescence Microscopy Recherche Immunologie Confocal Microscopy Bio Informatique Microscopie Immunohistochimie Antibodies Microscope Confocal Immunohistochemistry Bioinformatics Life Sciences Biologie Cellulaire Protein Expression And Purification

Thomas Bonacci Education Details

Frequently Asked Questions about Thomas Bonacci

What company does Thomas Bonacci work for?

Thomas Bonacci works for University Of North Carolina At Chapel Hill

What is Thomas Bonacci's role at the current company?

Thomas Bonacci's current role is Research assistant professor.

What is Thomas Bonacci's email address?

Thomas Bonacci's email address is th****@****unc.edu

What is Thomas Bonacci's direct phone number?

Thomas Bonacci's direct phone number is +191996*****

What schools did Thomas Bonacci attend?

Thomas Bonacci attended Université Paul Cézanne (Aix-Marseille Iii), Université Paul Cézanne (Aix-Marseille Iii), Université Du Sud Toulon Var.

What skills is Thomas Bonacci known for?

Thomas Bonacci has skills like Science, Biochemistry, Cell Biology, Molecular Biology, Culture De Cellules, Ubiquitin Like Proteins, Qpcr, Biochimie, Mass Spectrometry, Sciences De La Vie, Biotechnology, Anticorps.

Who are Thomas Bonacci's colleagues?

Thomas Bonacci's colleagues are Carrie Donley, Nil Aygün, Nathanaël Prunet, Lane F., Sandra Bogue, Emily Gadziola, Mba, Bill Stockard.

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