Thomas Frederick Email and Phone Number
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A biophysical chemist that specializes in protein NMR spectroscopy, molecular dynamics, and molecular modeling. Fragment based drug discovery.
Abbvie
View- Website:
- abbvie.com
- Employees:
- 46234
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Senior Scientist IiAbbvie Jun 2022 - PresentNorth Chicago, Illinois
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Senior Scientist IAbbvie Aug 2019 - Jun 2022North Chicago, IllinoisFragment based drug discovery.SAR by NMR.
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Postdoctoral Research AssociateWashington University School Of Medicine In St. Louis Jun 2016 - Jul 2019St. Louis, MoAdvisor: Gregory Bowman• Used molecular dynamics and Markov State Models to predict novel protein allosteric sites called ‘cryptic’ pockets.• Experimentally verified predicted cryptic pockets using UV based labeling experiments.• Used NMR relaxation to characterize the underlying dynamics of cryptic pocket formation.• Applied molecular modeling methods (e.g. in silico Boltzmann docking) to identify potential small molecule modulators of protein activity, specifically targeting allosteric sites.• Screened small molecules identified by in silico docking using NMR and plate-based assays.• Characterized Ebola virus protein-protein and protein-nucleic acid interactions to promote drug discovery initiatives as part of a multi-investigator team.• Mentored graduate students and laboratory technicians as the wet lab manager. • Interacted with external labs providing in silico docking and computational expertise. -
Graduate Research AssistantUniversity Of Notre Dame Jun 2010 - May 2016Notre Dame, InAdvisor: Jeffrey W. Peng• Used NMR methods including spectral density mapping and paramagnetic relaxation enhancement to understand the signal transduction process in the signaling protein BlaR1.• Performed resonance assignments of protein-ligand complexes and relevant protein variants.• Developed ligand-detected NMR pulse sequences to characterize the bound pose and dynamics of a small molecule covalently bound to a protein active site.• Implemented pulse sequences for use on Notre Dame’s Bruker NMR spectrometers. -
Undergraduate Research AssistantUniversity Of Florida Jan 2006 - May 2010Gainesville, FlAdvisor: Gail E. Fanucci• Characterized the membrane morphology and side-chain dynamics of an unusual phospholipid, bis(monoacylglycero)phosphate, involved in endosome maturation.• Employed multiple spectroscopic techniques including solid-state NMR, electron paramagnetic resonance, fluorescence, dynamic light scattering, and electron microscopy.
Thomas Frederick Skills
Thomas Frederick Education Details
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Chemistry
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Chemistry
Frequently Asked Questions about Thomas Frederick
What company does Thomas Frederick work for?
Thomas Frederick works for Abbvie
What is Thomas Frederick's role at the current company?
Thomas Frederick's current role is Senior Scientist II - Biophysics and Fragment Screening at AbbVie.
What is Thomas Frederick's email address?
Thomas Frederick's email address is tfrederick@nd.edu
What is Thomas Frederick's direct phone number?
Thomas Frederick's direct phone number is +157428*****
What schools did Thomas Frederick attend?
Thomas Frederick attended University Of Notre Dame, University Of Florida.
What skills is Thomas Frederick known for?
Thomas Frederick has skills like Nmr Spectroscopy, Protein Chemistry, Molecular Dynamics, Python, Data Analysis, Protein Expression, Protein Purification, Biophysics, Biochemistry, Physical Chemistry, Antibiotic Resistance, Spectroscopy.
Who are Thomas Frederick's colleagues?
Thomas Frederick's colleagues are Octavio Montero, Naaji Robinson, Cbcp, Ccrp, Deb Van Riet, Carlos Gutierrez, Adriana Zani, Isabella Carini, Fatiha Bouchetout, M.sc.
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Thomas Frederick
Global Continuous Improvement And Operational Excellence Professional | Lean Problem SolvingDetroit Metropolitan Area2cooperstandard.com, cooperstandard.com -
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Thomas Frederick
West Linn, Or8gmail.com, ole.com, yahoo.com, aol.com, harris.com, att.net, hotmail.com, lamresearch.com2 +171954XXXXX
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6clair-tech.com, yahoo.com, yahoo.com, swva.net, cswnet.com, clairvoyant-technology.com -
Thomas Frederick
Product Management & Customer Experience Specialist | Technology SolutionsKansas City Metropolitan Area3gmail.com, sprint.com, t-mobile.com2 +1 800-XXXXXXXX
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