Thomas Lefebvre Email and Phone Number
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Principal Scientist, PhD, with 15 years of leadership in Drug Discovery across immuno-oncology, neurosciences, and endocrinology, working in CRO, biotech, and start-up environments.Proven Project Leader with expertise in cell-based assay development and optimization, experience in animal models and drug development, driving early project proposals, Hit to Lead, Lead Optimization, and Preclinical programs to success.A highly skilled manager known for building and leading teams, fostering collaboration, and delivering results in fast-paced environments. People-oriented, with critical thinking and excellent communication, adept at motivating teams, managing complex projects, and ensuring strategic alignment.
Bright Peak Therapeutics
View- Website:
- brightpeaktx.com
- Employees:
- 51
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Principal ScientistBright Peak TherapeuticsAllschwil, Bl, Ch -
Principal Scientist - Discovery & PharmacologyInterax Biotech Jan 2024 - PresentVilligen, Aargau, Switzerland- Led the development of innovative medicines for metabolic diseases by leveraging molecular modeling, integrating artificial intelligence and kinetic modeling.- Led collaborations with CROs to characterize and evaluate drug candidates, focusing on optimizing drug-like properties and ensuring data reliability.- Optimized complex multiplex assays on primary cells to improve efficiency and data quality. -
Scientist, Lab HeadIdorsia Pharmaceuticals Ltd Jun 2017 - Jan 2024AllschwilProject Leader in Drug Discovery Immunology Biology:- Drove multiple Drug Discovery projects within multidisciplinary teams (Chemistry, Pharmacology and DMPK), leading target identification and assay development for target validation and screening.- Established and managed strategic collaborations with academic labs, while developing predictive assays using primary human cells.- Led binding assays (radioligand and FRET-based assays).- Co-developed innovative animal models to support preclinical research and therapeutic evaluation.- Managed a Team of 2 to 3 Research Associates. Mentored and guided trainees and apprentices to enhance lab performance and skill development. -
Associate ScientistActelion May 2014 - Jun 2017Bâle Et PériphérieDrug-discovery - Immunology Biology:- Led and contributed to multiple drug discovery projects within multidisciplinary teams.- Designed plasmids, developed cell lines and assays for target validation and High Throughput Screening.- Directed SAR efforts and oversaw translational biomarker development for target engagement and efficacy assessment in clinical trials. -
Scientist, Project LeaderSynaging Dec 2010 - Apr 2014Région De Nancy, France- Managed CRO activities from protocol setup with clients to sample tracking, data management, and statistical analysis, leading to comprehensive reporting.- Led drug discovery projects from target identification to the establishment of stable cell lines and deorphanization, progressing to High Throughput Screening.- Developed innovative research programs, including the creation of novel animal models for Alzheimer's disease.
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Associate Scientist/ConsultantActelion Pharmaceuticals Ltd Dec 2010 - May 2012Région De Basel, SuisseDrug-discovery in CNS Biology.- Cell culture: recombinant mammalian cell lines (transfection, clone selection and validation).- Cell-based assays linked to GPCRs signaling: calcium measurement (FlipR), cAMP release (HTRF and luciferase reporter assays), Beta-arrestin recruitment, label free, dimerisation, cell proliferation and cytotoxicity assays.- FACS and Q-RT-PCR to validate receptor expression.- SiRNA-mediated gene silencing. -
PhdUnité Inserm 413 Nov 2005 - Mar 2010Région De Rouen, FranceStudy of a bi-directional functional cross-talk between the GABA(A) ion channel receptor and the urotensine II receptor: implication in the astrocyte physiology. Work performed in the Laboratory of cellular and molecular neuroendocrinology - Inserm U413. PhD Advisor: Dr. Hélène Castel. Design of electrophysiological protocols, develop a neurones/astrocytes co-culture model from cerebellum, real-time calcium release monitoring, dimerisation studies, pharmacological profile of native receptors, immunohistochemistry, confocal microscopy.
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Teaching Assistant (Ater)Université De Rouen - Inserm U413 Sep 2008 - Aug 2009Région De Rouen, FranceTeaching at graduate until post-graduate levels (lecture and practical). Neurophysiology, Embryology and Molecular Biology.
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Doctorant-ConseilActelion Pharmaceuticals Ltd Jan 2009 - Mar 2009Région De Basel, SuisseVoluntary internship initiated during my PhD fellowship.Transfection, clone selection and validation of recombinant cell lines. Small molecules screening (fluorescence and membrane potential recording) and data analysis.
Thomas Lefebvre Skills
Thomas Lefebvre Education Details
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Biologie Cellulaire - Neurosciences -
Biologie Et Physiologie Cellulaire - Neurosciences -
Biologie Cellulaire Et Physiologie -
Université Du HavreSciences De La Vie
Frequently Asked Questions about Thomas Lefebvre
What company does Thomas Lefebvre work for?
Thomas Lefebvre works for Bright Peak Therapeutics
What is Thomas Lefebvre's role at the current company?
Thomas Lefebvre's current role is Principal Scientist.
What is Thomas Lefebvre's email address?
Thomas Lefebvre's email address is le****@****ail.com
What schools did Thomas Lefebvre attend?
Thomas Lefebvre attended Université De Rouen, Université De Rouen, Université De Rouen, Université Du Havre.
What skills is Thomas Lefebvre known for?
Thomas Lefebvre has skills like High Throughput Screening, Cell Biology, Electrophysiology, In Vivo, Animal Behavior, Culture De Cellules, Neurosciences, Sciences De La Vie, Essais Sur Des Cellules, Biologie Cellulaire, Alzheimer's Disease, Pre Clinical.
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Thomas LEFEBVRE
Geneva -
2gmail.com, johnsonelectric.com
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Thomas LEFEBVRE
Informaticien | Développement Et Support | Programmation C++ / C# / Java | Fr / EngBern -
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