Thomas Lee, Ph.D. Email & Phone Number

Established Orna’s second-generation panCAR for autoimmunity & immuno-oncology DCs- Led Orna’s next-generation panCAR for immuno-oncology & autoimmunity to select 2 developmental candidates- Developed in vivo models for panCAR evaluation for immuno-oncology & autoimmunity targets- Developed in vitro assays to evaluate Orna’s platform in cynomolgus & rhesus.

Cambridge, Massachusetts, United States

Platform Application - Exploratory & Expansion Team- Project: Expand the application of the circular RNA platform in various in vitro & in vivo disease models.- Team lead for the Platform Expansion team, focusing on molecular immunology, immunogenicity, infectious diseases, & immuno-oncology.Project: ORN101 - In the latter half of 2021, lead a team to.

Greater Boston

Project: ORN101 - Orna's first immuno-oncology pipeline program- 1st immunologist & 5th employee at Orna Therapeutics - Led the team to investigate future immuno-oncology & exploratory pipeline programs- Initiated pre-clinical studies evaluating LNP-delivery of oRNA in an immuo-oncology model (syngeneic models)- Supported & assisted the development of.

Greater Boston Area

Project: Utilize the SQZ platform to develop a novel pre-clinical, cell-based therapy to establish immuno-homeostasis in autoimmunity.Research- Designed and implemented experiments compiled into a pre-clinical package for type 1 diabetes (T1D).- Collaborated with multidisciplinary teams to evaluate islet-antigen, protein targets, and protein.

Houston, Texas Area

PhD candidate in the Immunology ProgramDepartment: Immunology and EndocrinologyThesis Topic: Strengthening Central Tolerance to Prevent T cell-mediated AutoimmunityPI: Matthew BettiniFunding:- American Association of Immunologist Careers in Immunology Fellow (2016-2017)Research:- Generated retroviral mediated transgenic mice (retrogenics) to study islet.

Dallas/Fort Worth Area

In collaboration with UTSW’s Allergy and Asthma Clinic as well as the Inner City Asthma Consortium, I was involved in a NIH/NIAID funded clinical trial testing the efficacy of a novel sublingual immunotherapy (SLIT) to treat asthma by administering cockroach (CR) antigen. In this translational study, I designed one leg of the project that used blood.

Under the mentorship of Dr. Nitin Karandikar MD, Ph.D, I investigated regulatory T cells (Tregs) and their role in the adaptive immune response. Tregs are key in preventing the immune system from progressing towards autoimmunity or self-reactivity. In the course of our research, I discovered that transient expression of the intracellular transcription.