Thomas Brubaker Email & Phone Number

South San Francisco, California, United States

South San Francisco, California, United States

- Prepared and analyzed samples on various analytical instrumentation (HPLC, dissolution, Karl-Fischer, XRPD, DSC, TGA, microscopy)- Developed and prepared formulations for preclinical studies- Designed and executed scientific experiments to support all aspects of small molecule drug development (eg, stability studies, method qualification, compound characterization, formulation evaluation, solubility studies, salt screening)- Summarized and communicated data and results to other team members via written reports and oral presentations- Managed lab equipment, performed general upkeep of the laboratory, and served as the point of contact with external service, instrument, and materials vendors- Authored, edited, and reviewed SOPs for instruments and data administration- Reviewed batch records, stability data, and reports from external manufacture and research organizations - Helped oversee the production of drug substance and product for clinical trials, evaluated data from PR&D to improve production processes- Analyzed data from stability testing of drug substance and drug product, used the analyses and regulatory guidelines to determine justifiable retest periods for the materials on stability - Generated and issued stability reports which detail data analysis, along with new CoAs and associated documents- Created and maintained tools for efficient display, access, and processing of CMC data

Lawrence Berkeley National Lab

- Created new formulations of acrylate polymers to optimize a hydrophobic coating for industrial use - Tested physical and chemical properties of new coatings to determine the best direction for future tests- Tested varying oligomers, cross-linkers, hardeners, and initiators to determine more ideal formulations - Used FTIR and XPS to analyze the chemical makeup of the thin film coatings - Used spectral reflectance measurements to determine film thickness - Kept diligent and up to date records of all formulations, tests, and results - Reported and discussed findings and future goals in weekly meetings with the research and management teams

- Primary analyst in studies tracking the degradation of bioactive molecules in soil and water systems.- Maintained lab notebook, raw data, and instrument records in GLP and SOP compliance.- Frequently used both normal and reversed phase HPLC analysis to purify and quantify degradates.- Performed method development to optimize separation.- Used LC/MS/MS to identify unknown products- Extracted compounds from complex media using a variety of methods.- Developed extraction and concentration procedures when necessary.- Used 2D TLC to confirm compound identification.- Maintained data records in hard copy and in excel spreadsheets.

University Of California, Riverside

Optimized a new organic synthesis that stemmed from a PhD candidate's project.Purified and characterized the products.

University Of California, Riverside

Worked on the chemical genetics project of Andrew Defries, PhD.Specialized in the purification of small molecules.Performed some synthesis of small molecules.

Bachelor Of Science (B.S.), Biology, General

Bachelor Of Science (Bs), Cell/Cellular And Molecular Biology