Tim Graham Email & Phone Number

California, United States

San Diego, California

• A wholly owned and independently operated subsidiary of Bayer.
• Clinical program manager supporting a Phase I immuno-oncology program for an oral small molecule inhibitor of STAT3 transcription factor developed for the treatment of advanced solid and hematologic tumors.
• Program manager for two IND enabling immunology programs.

San Francisco Bay Area

• Formally Global Blood Therapeutics before acquisition by Pfizer.
• Clinical Asset Project Manager and Alliance Manager supporting the rare disease clinical and pre-clinical portfolio.
• Clinical project manager for a Phase III hematology program, Inclacumab, which is a monoclonal antibody inhibitor of p-selectin that aims to reduce the occurrence of vaso-occlusive crises (VOCs) and hospital.
• Project manager for two IND enabling hematology programs.

San Francisco Bay Area

• Clinical program manager supporting Phase IV post marketing requirements and Phase III international label expansion in Japan for Palynziq, an enzyme substitution treatment for lowering blood phenylalanine.
• Developed and instituted new processes to build out a PMO infrastructure within the Research organization.

San Francisco Bay Area

• Oversaw the program operations of Translational Biology to support IND enablement of novel therapies for a portfolio of genetic rare diseases.
• Directly managed outsourced pre-clinical initiatives, partnering with a range of contract research organizations and strategic alliances.

San Francisco Bay Area

Sacramento, California, United States

• Directly managed a portfolio of large, complex in-vivo projects with budgets of up to $10 million as part of a Contract Research Organization (CRO) for a range of clients in the pharmaceutical, biotechnology, and.
• Provided key knowledge and strategic support for a wide variety of services covering microbiology andCRISPR studies to in-vivo drug studies and large-scale mouse breeding.

Houston, Texas, United States

• Pediatric neuro-oncology research under the mentorship of Dr. Patrick Zweidler McKay and Dr. Joseph McCarty, Department of Pediatric Oncology.Evaluated the importance of neurotrophin receptors (TRK) and integrin.
• Discovered the relationship between the Src family member, Fyn, and TrkB as an important regulator of differentiation in neuroblastoma.
• Identified that αVβ8 integrin expression is regulated via Ras as a novel pathway important for neurovascular development between neural cells and blood vessels in the CNS.
• Designed and implemented a phospho-flow based assay to assess the effects of Fyn retroviral/lentiviral constructs of SRC/FYN phosphorylation as a downstream regulator of TrkB activation.
• Established an orthotopic xenograft mouse model (via intra-adrenal injection) and luciferase-based whole model imaging to monitor tumor progression and metastases.

Houston, Texas, United States

• Neurodegenerative diseases research under the mentorship of Dr. Pramod Dash and Dr. Andrew Papanicolaou, Department of Neurobiology and AnatomyEvaluated therapeutic approaches to alleviate the memory disorders.
• Identified and analyzed biomarkers in the CA3 region of the hippocampus of traumatically brain injured rats.
• Conducted Morris water maze tasks to analyze the therapeutic efficacy of drugs on the working memory of traumatically brain injured rats.
• Created and implemented a language task to evaluate the therapeutic potential of acoustic tones of key words to help memory formation in pre/post stroke patients as analyzed by MEG (magnetoencephalography) imaging.
• Helped direct and run the clinical trial for stroke patients under Dr. Joshua Breier (PI of study).

Fort Worth, Texas, United States

• Chemical synthesis and tissue engineering research under the mentorship of Dr. Tracy Hanna, Dr. Jeffery Coffer, and Dr. Robert Neilson, Department of ChemistryDeveloped new catalytic methods for the synthesis of.
• Assembled/utilized Schlenk line to perform catalytic reactions.
• Helped engineer and establish a novel technique called electro-spinning to produce a biopolymer scaffold.
• Verified structure of chemical compounds with 2D-NMR spectroscopy and mass spectrometry.
• Analyzed biological activity of engineered tissues by scanning electron microscopy.

Master Of Business Administration - Mba, Entrepreneurship And Strategic Innovation / Global Business

Activities and Societies: Leadership in Action

Master Of Science - Ms, Neuroscience

Activities and Societies: Neuroscience Graduate Student Council

Bachelor Of Science - Bs, Biochemistry

Activities and Societies: Founder and President of the TCU chapter for the American Chemical Society