Tom Barta Email & Phone Number

Carrboro, NC, US

Carrboro, NC

°Esperion Therapeutics, Inc. (11/2020-8/2023). IP and med chem guidance on small molecule PCSK9 lipid modulators.°Biotechs in various therapeutic areas: metabolism (ASBT), cancer (kinases, adenosine modulators), inflammation (various inflammasome proteins).

Carrboro, NC

°Organic and med chem consulting emphasizing scaffold design and optimization. AutoDock, PyMol °Med chem, synthesis planning, CRO management, IP expansion, competitive intelligence.

°Developed small, non-statin molecules for lowering cholesterol. (PCSK9 modulators. For an early review see https://doi.org/10.1016/j.bmcl.2018.02.046)°The program was licensed to Esperion 11/2020

Chapel Hill, NC

Spanned the gap between med chem and computational chem. Used Monte Carlo annealing methods to optimize delta G of binding for virtual fragments and med chem expertise to craft useful and patentable nanomolar enzyme inhibitors.Managed internal projects (renin) and worked with clients from drug (furin, heat shock 90, citrate lyase), agricultural (tryptophan.

Durham, NC

• Drug Discovery Chemistry.
• Designed, prepared, and scaled picomolar Heat Shock 90 inhibitors and worked on other kinase programs related to oncology. Our orally-active HSP90 candidate went into clinical trials.
• Pursued other targets, including aurora kinase, tubulin, DHFR and TGF-B.Representative Publications:"Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active.

Skokie, IL

• Drug Discovery Chemistry.
• Designed Cyclooxygenase II inhibitors with >1000 fold selectivity and activity in efficacy models for arthritis. The COX-2 program led to two approved drugs..
• Designed and synthesized highly selective, orally bioavailable hydroxamic acid Matrix Metalloproteinase inhibitors for use as cancer, cardiovascular, and arthritis therapeutics, obtaining 17 issued US patents. The MMP.
• Responsible for coordination of the lead identification phase of the Aggrecanase program. A number of file compounds with potencies of 30 nM and better were discovered.
• Other projects include: use of a stereospecific aziridinium-ion mediated rearrangement to synthesize novel amino-sugar anti-HIV glucosidase inhibitors; SAR of 5-LO inhibitors for asthma; and an exploratory effort to.

Post Doc, Organic Chemistry

NIH Postdoctoral Fellowship Worked with Prof. Anthony G.M. Barrett

Phd, Organic Chemistry

Worked with Prof. Robert K. Boeckman

Bs, Chemistry