Co-Founder
Current# Aging and cancer.# Preventing relapses in autoimmunity.
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@hifibio.com
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1 phone found area 267
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Tom Stephen is listed as Co-Founder | Serial Entrepreneur | Drug Developer | Scientist- Immunologist and Immuno-Oncologist at Stealth - Therapeutics Biotech, based in Greater Boston, United States. AeroLeads shows a work email signal at hifibio.com, phone signal with area code 267, and a matched LinkedIn profile for Tom Stephen.
Tom Stephen previously worked as Co-Founder at Stealth - Therapeutics Biotech and Senior Principal Scientist at Hifibio Therapeutics. Tom Stephen holds Phd, Immunology And Microbiology from University Of Cologne.
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An Immuno-Oncologist (I-O) with 20 years of research experience investigating anti-tumor immunity, tumor microenvironment (TME), immune tolerance, and autoimmunity, including eight years of biopharmaceutical experience in leading drug discoveries, managing projects, and teams. A team player and collaborative scientist with a strong passion for innovative drug discoveries for unmet patient needs.
Listed skills include Animal Models, Cell, Flow Cytometry, Western Blotting, and 21 others.
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# Aging and cancer.# Preventing relapses in autoimmunity.
Cambridge, Massachusetts, Us
# Project lead, Monoclonal and Bispecific antibodies. # Immuno-Oncology/Disease Biology Lead# Project management
Princeton, New Jersey, Us
Program Lead, Immune Tolerance# Led the discovery and optimization of novel immune tolerance therapies for viral gene therapy, driving innovative solutions from concept to preclinical development.# Managed cross-institutional academic collaborations to accelerate research progress and enhance scientific output.# Supervised and provided strategic direction to direct reports and external contract research organizations (CROs).
Cambridge, England, Gb
# Lead new Immuno-Oncology Bicyclic peptide discoveries.# Lead target selection and validation studies# Biology support for 4-1BB/Nectin-4 T cell engagers (TICA's)# Project lead for Bicycle-STING, Bicycle-TLR agonist drug conjugates (BDCs)
Cambridge, Cambridgeshire, Gb
# Lead, Immuno-Oncology small molecular drug discoveries# Immuno-Oncology support for the A2AR Phase 1 program# Due Diligence lead for Immuno-Oncology assets
Boston, Massachusetts, Us
IO New targets & biomarker discovery # Led biomarker strategies for M7824 (anti-PD-L1/TGF-b Trap) bi-functional antibodies # Led new concept project to enhance tumor immunogenicity # IO Due Diligence member for novel immune modulators
Philadelphia, Pa, Us
Discovered novel immune regulatory mechanisms in solid tumor microenvironment (TME).# Investigated T cells anti-tumor immunity in cancer.# Discovered TGFb/SATB1 in epigenetic regulation of PD-1 in solid tumors. (Immunity 2017).# Discovered TGFb/Foxp1 pathway in T cell inhibition in solid tumors (Stephen TL, Immunity 2014).# Mastered in techniques: T cell, DC, NK, Mφ, MDSC, Treg assays, 18C-FACS, ChIP/Seq, and Confocal Microscopy.# Developed mouse tumor models. # Review member; immunology journals. # Committee member, Wistar community outreach programs. # Trained graduate students, postdoctoral fellows, biomedical technicians, and RAs.# Winner of AAI Travel Award 2012
Philadelphia, Pa, Us
Identified mechanisms of T cell central (thymic) tolerance in autoimmunity.# Winner of Arthritis Foundation-awarded. # Investigated T cell central tolerance and autoimmunity. # Discovered Lck kinase in central tolerance induction (Stephen TL, PNAS 2012). # Trained graduate students and 4 RA's.
Cologne, North Rhine-Westphalia, De
Investigation of antigen processing and presentation# Identified novel antigen processing and presentation pathway for zwitterionic polysaccharides (ZPS) of S. Pneumonia# First to demonstrate MHC Class II-dependent CD4 T cell activation by ZPS# Identification co-stimulatory pathways in ZPS-mediated T cell activation
Worked as a research fellow in the Acute Myeloid Leukemia group of the University of Munich.# I studied the molecular mechanisms and pathogenesis of human Acute Myeloid Leukemia (AML) in experimental (mouse) models.
Participated in the Lymphatic filarial vaccine project of Indian Council for Medical Research (ICMR). # Established the rat-mosquito-rat experimental model for Brugia malayi, the causative agent of human lymphatic filaria. # Learned various in vitro and in vivo techniques, including handling and processing of human tissues.
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Tom Stephen works for Stealth - Therapeutics Biotech.
Tom Stephen is listed as Co-Founder | Serial Entrepreneur | Drug Developer | Scientist- Immunologist and Immuno-Oncologist at Stealth - Therapeutics Biotech.
AeroLeads has found 1 work email signal at @hifibio.com for Tom Stephen at Stealth - Therapeutics Biotech.
AeroLeads has found 1 phone signal(s) with area code 267 for Tom Stephen at Stealth - Therapeutics Biotech.
Tom Stephen is based in Greater Boston, United States while working with Stealth - Therapeutics Biotech.
Tom Stephen has worked for Stealth - Therapeutics Biotech, Hifibio Therapeutics, Luye Pharma Usa Ltd., Bicycle Therapeutics, and Astrazeneca.
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Tom Stephen holds Phd, Immunology And Microbiology from University Of Cologne.
Tom Stephen is listed with skills including Animal Models, Cell, Flow Cytometry, Western Blotting, Molecular Biology, Cell Culture, Pcr, and Qpcr.
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