Graduate Researcher - Nanoprobes For Optical Imaging And Laser Therapy Of Cancer
Galway, Ireland
• Nanostructure synthesis and characterisation- Successful wet-chemical synthesis of various colloidal anisotropic nanostructures with visible and near infrared (NIR) localised surface plasmon resonance (LSPR)- Nanoparticle characterisation using electron microscopy (HRTEM and SEM), UV-Vis-NIR spectrophotometer, AFM, zeta potential analyzer, DLS, ICP-MS, AAS, etc.- Surface functionalisation with peptides and synthetic polymers- Nanoparticle contrast based fluorescence and Raman (SERS) imaging• Nanofabrication of plasmonic gold nanostructures for Biosensing• Experience in cell culture techniques including optimisation of cellular uptake, cytotoxicity and physico-chemical characterization of the bio-conjugated nanoprobe• Thermo-plasmonics and in vivo Optical Imaging- Successful pre-clinical study of NIR laser (1064 nm) induced photothermal therapy using plasmonic gold nanostars in mice model- In vivo Optoacoustic/Ultrasound monitoring of Photothermal therapy• Optical instrumentation- Experience with in-house experimental laser setups using gas and solid state lasers- Optimisation of DPSS and nanosecond laser irradiation for in vivo photothermal treatment • Optical modelling of laser-material interaction using finite-difference time-domain (FDTD) method and finite element method (FEM) using COMSOL Multiphysics and DEVICE• Secondment at National Cancer Centre Singapore for 7 months for a collaborative project on nanoparticle induced laser therapy of cancer • Collaborated with clinicians and scientists from various specialties and communicating with research groups across different time zones, resulting in publication of multiple research reports and articles