Virginia Le Verche, Phd Email & Phone Number

Monrovia, California, US

Duarte, CA, US

Strategic and Regulatory Consulting for Cell and Gene Therapy.Our mission is to accelerate the development of cell and gene therapies from preclinical stage to FDA-approved products and disease cures. Our team of experts provides preclinical, clinical, manufacturing, and regulatory support to biomedical companies and academic institutions to help you bring.

Duarte, CA, US

• Support preclinical and clinical project management for the Center for Gene Therapy of the Hematologic Malignancies and Stem Cell Transplantation Institute at City of Hope.
• Coordinate clinical trial design, writing and submission of clinical protocols, informed consent forms and Investigational New Drug (IND) for the treatment of brain cancer, HIV/AIDS or sickle cell disease using gene or.
• Collaborate with laboratory and clinical researchers to organize manuscript writing, data presentation and article submission.
• Wrote two grant applications that were awarded over $7M by the California Institute for Regenerative Medicine (CIRM).
• Assist with identification of funding opportunities, grant writing and submission.

New York, NY, US

• The SMA Foundation is a non-profit biomedical research foundation focused on advancing the development of therapeutics for Spinal Muscular Atrophy. The Foundation is the second largest funder of SMA research worldwide.
• Identified and evaluated new scientific and drug development opportunities with a special emphasis on muscle-enhancing therapies (anti-myostatin antibodies, SARMs, mitochondria biogenesis stimulators), medical devices.
• Prepared materials on the therapeutic and commercial potential of SMA to convince companies developing therapies for muscle wasting disorders (Duchenne muscular dystrophy, cancer cachexia, sarcopenia, COPD or hip.
• Supported project teams by coordinating research activities both internally and externally with major pharmaceutical or biotech companies, academic institutions and CROs to move therapeutic candidates through.
• Authored and reviewed MTAs, CDAs, budgets, executive summaries of project or Foundation activities used for strategy decisions.
• Performed site visits and represented the Foundation at international scientific meetings.

New York, New York, US

• Successfully developed the first fully humanized model of sporadic ALS
• Discovered a necroptotic pathways that is triggered in motor neurons by sporadic and familial ALS astrocytes
• Identified potential toxic factor released by toxic ALS astrocytes
• Forged partnership with industry to develop AAV mediated gene therapy technology in the Motor Neuron Center,the Target ALS research initiative, and Biogen Idec
• Designed and executed preclinical studies testing AAV-shRNA mediated therapy in ALS animal models
• Developed behavioral paradigms (loaded grid and inverted screen tests) for assessing grip strength in ALS animal models for the Motor Neuron Center and affiliated scientists

New York, New York, US

• Executed in vitro drug screening to characterize the non-cell autonomous toxic mechanisms in ALS: identified key elements of the death cascade activated in motor neurons upon exposure to familial ALS astrocytes
• Successfully tested the cytotoxic properties of mutant glial restricted precursor graft in the spinal cord of healthy rat (collaboration with Johns Hopkins ALS research team)
• Designed and executed two preclinical studies to test the neuroprotective properties of small molecules in ALS mouse model (collaboration with the Scripps Research Institute, Florida)
• Editorial reviewer for Gene, Neuropharmacology and Journal of Neurochemistry
• Awarded a R21 grant as co-investigator
• Supervised undergraduate students (2 years)

Paris, 13, FR

• Fully characterized the expression profile of somatostatin receptor sst2A in the developing rat and human brain and identified its role in neuronal migration.
• Developed expertise in the normal and pathological brain development.
• Imported cell migration assays and video microscopic technic in the laboratory.
• Selected for two years as teaching fellow in Neurophysiology for Psychology Bachelor students at the Psychology Institute and was fully responsible for the content of the class being taught.
• Produced four publications in PloS One, Stem Cells and Development, Developmental Neurosciences and Journal of Neuroscience and one book chapter in Cambridge University PressAwards and honors: Summa Cum Laude, Research.

Certification Of Professional Achievement In Business, Management, Entrepreneurship, Leadership, Resolution Of Conflicts, Marketing

Doctor Of Philosophy (Ph.D.), Cellular And Molecular Neurobiology

Bachelor Of Science (B.S.), Major In Cell Biology And Physiology. Minor In Animal Physiology