Lois Wright Email & Phone Number

Cary, NC

Cary, NC

Raleigh-Durham, North Carolina Area

• Assay development and compound profiling scientist in drug discovery identifying and evaluating hits, leads and drug candidates for human diseases.
• Designed the test, acquired the data, and created a model that explained the slow binding kinetics of compounds to a protein target
• Led the implementation of, and individually developed, a test to reduce compound attrition; participated on the global team that rolled out a new attrition reduction initiative
• Developed, as a key contributor on a diverse team, a web-based tool, replacing email communication and Excel spreadsheets, used by scientists to request compounds for testing, which resulted in automated notifications.
• Changed the status quo by suggesting and helping to implement infectious material tests in the screening department; normally the tests occurred in the anti-viral department

Raleigh-Durham, North Carolina Area

• Led the project team that discovered a compound which inhibited a target thought to be involved in cardiovascular disease
• Recognized the need to coordinate instrument use across departments; created the team that implemented business rules for instrument use
• Discovered a novel interference effect that led to a reduction of false positives during testing of compounds saving valuable resources
• Trained new users and assisted current users with the operation of a highly technical instrument after completion of comprehensive training in Finland, the location of vendor headquarters

Raleigh-Durham, North Carolina Area

• Discovered that inhibition of a protein target by a specific class of compounds was an artifact, which halted efforts on the compound class, saving time and resources
• Confirmed, using equations to model the tight binding effect of the compound, that the inhibition of HIV-1 protease by the prodrug candidate was due to the presence of a small amount of active drug substance, 0.37%.
• Mathematically modelled and experimentally confirmed the initial binding of nucleoside triphosphates, including AZT-triphosphate, to HIV-1 reverse transcriptase to understand ligand-protein interactions and assist drug.

Master Of Science - Ms, Analytics

Master Of Science - Ms, Analytics

M.S. in Analytics at the Institute for Advanced Analytics

Master Of Science - Ms, Physics

Teaching assistant - Introductory physics laboratory sessions Research assistant - UNC Chemistry Department, studied the biophysical.

Bachelor Of Science - Bs, Physics And Mathematics

Activities and Societies: Sigma Pi Sigma (The Physics Honor Society), Varsity Basketball (4 years) and Varsity Softball (3 years)