Lois Wright Email & Phone Number

Cary, Nc

Cary, Nc

Raleigh-Durham, North Carolina Area

Assay development and compound profiling scientist in drug discovery identifying and evaluating hits, leads and drug candidates for human diseases.• Designed the test, acquired the data, and created a model that explained the slow binding kinetics of compounds to a protein target• Led the implementation of, and individually developed, a test to reduce compound attrition; participated on the global team that rolled out a new attrition reduction initiative • Developed, as a key contributor on a diverse team, a web-based tool, replacing email communication and Excel spreadsheets, used by scientists to request compounds for testing, which resulted in automated notifications when requests were filled and hours of time saved• Changed the status quo by suggesting and helping to implement infectious material tests in the screening department; normally the tests occurred in the anti-viral department

Raleigh-Durham, North Carolina Area

• Led the project team that discovered a compound which inhibited a target thought to be involved in cardiovascular disease• Recognized the need to coordinate instrument use across departments; created the team that implemented business rules for instrument use• Discovered a novel interference effect that led to a reduction of false positives during testing of compounds saving valuable resources• Trained new users and assisted current users with the operation of a highly technical instrument after completion of comprehensive training in Finland, the location of vendor headquarters

Raleigh-Durham, North Carolina Area

• Discovered that inhibition of a protein target by a specific class of compounds was an artifact, which halted efforts on the compound class, saving time and resources• Confirmed, using equations to model the tight binding effect of the compound, that the inhibition of HIV-1 protease by the prodrug candidate was due to the presence of a small amount of active drug substance, 0.37%, helping progress the drug to market which reduced pill burden for patients• Mathematically modelled and experimentally confirmed the initial binding of nucleoside triphosphates, including AZT-triphosphate, to HIV-1 reverse transcriptase to understand ligand-protein interactions and assist drug discovery

Master Of Science - Ms, Analytics

Master Of Science - Ms, Analytics

M.S. in Analytics at the Institute for Advanced Analytics

Master Of Science - Ms, Physics

Teaching assistant - Introductory physics laboratory sessions Research assistant - UNC Chemistry Department, studied the biophysical.

Bachelor Of Science - Bs, Physics And Mathematics

Activities and Societies: Sigma Pi Sigma (The Physics Honor Society), Varsity Basketball (4 years) and Varsity Softball (3 years)