Xia Chen

Xia Chen Email and Phone Number

Research Scientist at Syneos Health (Previously INC Research/inVentiv Health) @
Xia Chen's Location
Ridgefield, Connecticut, United States, United States
Xia Chen's Contact Details
About Xia Chen

I am an experienced pharmaceutical research scientist with 10+ years of experience in drug discovery and development at Boehringer Ingelheim, Schering-Plough Research Institute, and Merck Research Labs, with demonstrated success in lead compound identification, target validation, and lead optimization.Key Professional Highlights //-- Core team member in the discovery and development of BACE inhibitor MK-8931, which is currently in human phase III clinical trials for treatment of Alzheimer's Disease.-- Extensive experience in assay development, cell-based assays, protein biochemistry, immunoassay development and biomarker analysis for measuring beta-amyloid peptides and related proteins in CSF, plasma, and brain tissues of rodent, non-human primate and human subjects.-- Experienced in high-throughput compound screening in support of lead optimization using state-of-the-art laboratory automation platforms.

Xia Chen's Current Company Details
Syneos Health (Previously INC Research/inVentiv Health)

Syneos Health (Previously Inc Research/Inventiv Health)

Research Scientist at Syneos Health (Previously INC Research/inVentiv Health)
Xia Chen Work Experience Details
  • Syneos Health (Previously Inc Research/Inventiv Health)
    Senior Research Scientist
    Syneos Health (Previously Inc Research/Inventiv Health) Jun 2017 - Present
    Princeton, Nj
  • Covance
    Research Scientist
    Covance Jun 2015 - Jun 2017
    Trenton, Nj
  • Boehringer Ingelheim
    Scientist Iv
    Boehringer Ingelheim Jun 2014 - Jun 2015
    Ridgefield, Ct
    New Biological Entity Group• Develop and execute cell based assays to screen candidate antibodies for a various research projects.
  • Merck Research Laboratories
    Rotation, Assay Operations Group
    Merck Research Laboratories Apr 2013 - Nov 2013
    Kenilworth, Nj
    One of 17 experienced franchise-group scientists chosen to bolster Pharmacology in the development of key priority projects. Gained experience with intensified training and performance on high throughput compound screening with laboratory automation.Highlights //-- Supported transfer of aspartic protease counter-screen assays by setting up fully integrated large platform (BioCel) automation system, and successfully performing all screens under multiple assay conditions in one day.-- Developed and validated multiple aspartic protease counter-screens in 1536 well plate format.
  • Merck Research Laboratories
    Scientist, Neurodeneration
    Merck Research Laboratories 2009 - Apr 2013
    Kenilworth, Nj
    Supported virtually all the internal BACE program bio-marker needs.Developed significant hands on experience in Aß bio-marker analysis with ELISA assay, generated critical data on BACE inhibitor target engagement.Execution and analysis of MK-8931 micro-hemorrhage study designed to support communications with the FDA.Validated Meso Scale CSF BACE bio-marker assays in collaboration with Merck Clinical diagnostics lab. The improved assays are now being used to support all BACE clinical studies.
  • Schering-Plough Research Institute
    Scientist I/Ii, Neurodegeneration
    Schering-Plough Research Institute 1999 - 2009
    Kenilworth, Nj
    Performed core responsibility of determining BACE inhibitor IC50s with a cell based assay.Developed and Established multiple new ELISA assays for measuring sAPPb in biological samples.Set up numerous radio-ligand binding assays for counterscreens.Developed Ca+ FLUPR based primary assay for chemokine receptor signaling (e.g. CX3CR1 in microglia)Used siRNA to define the relative contributions of BACE1 and BACE2 to Aß production in HEK293 cells.Genotyping and full characterization of BACE2 knockout mouse generated from DeltagenCloning, expressing and biochemical characterization of human BACE2 in sf9 cells.

Xia Chen Skills

Drug Discovery Assay Development Drug Development Biomarkers In Vitro Pharmacology High Throughput Screening Protein Chemistry Biochemistry Immunoassays Cell Biomarker Discovery Elisa

Xia Chen Education Details

  • Beijing Normal University
    Beijing Normal University
    Chemistry

Frequently Asked Questions about Xia Chen

What company does Xia Chen work for?

Xia Chen works for Syneos Health (Previously Inc Research/inventiv Health)

What is Xia Chen's role at the current company?

Xia Chen's current role is Research Scientist at Syneos Health (Previously INC Research/inVentiv Health).

What is Xia Chen's email address?

Xia Chen's email address is xi****@****hoo.com

What is Xia Chen's direct phone number?

Xia Chen's direct phone number is +190822*****

What schools did Xia Chen attend?

Xia Chen attended Beijing Normal University.

What skills is Xia Chen known for?

Xia Chen has skills like Drug Discovery, Assay Development, Drug Development, Biomarkers, In Vitro, Pharmacology, High Throughput Screening, Protein Chemistry, Biochemistry, Immunoassays, Cell, Biomarker Discovery.

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