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I am an experienced pharmaceutical research scientist with 10+ years of experience in drug discovery and development at Boehringer Ingelheim, Schering-Plough Research Institute, and Merck Research Labs, with demonstrated success in lead compound identification, target validation, and lead optimization.Key Professional Highlights //-- Core team member in the discovery and development of BACE inhibitor MK-8931, which is currently in human phase III clinical trials for treatment of Alzheimer's Disease.-- Extensive experience in assay development, cell-based assays, protein biochemistry, immunoassay development and biomarker analysis for measuring beta-amyloid peptides and related proteins in CSF, plasma, and brain tissues of rodent, non-human primate and human subjects.-- Experienced in high-throughput compound screening in support of lead optimization using state-of-the-art laboratory automation platforms.
Syneos Health (Previously Inc Research/Inventiv Health)
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Senior Research ScientistSyneos Health (Previously Inc Research/Inventiv Health) Jun 2017 - PresentPrinceton, Nj
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Research ScientistCovance Jun 2015 - Jun 2017Trenton, Nj -
Scientist IvBoehringer Ingelheim Jun 2014 - Jun 2015Ridgefield, CtNew Biological Entity Group• Develop and execute cell based assays to screen candidate antibodies for a various research projects. -
Rotation, Assay Operations GroupMerck Research Laboratories Apr 2013 - Nov 2013Kenilworth, NjOne of 17 experienced franchise-group scientists chosen to bolster Pharmacology in the development of key priority projects. Gained experience with intensified training and performance on high throughput compound screening with laboratory automation.Highlights //-- Supported transfer of aspartic protease counter-screen assays by setting up fully integrated large platform (BioCel) automation system, and successfully performing all screens under multiple assay conditions in one day.-- Developed and validated multiple aspartic protease counter-screens in 1536 well plate format.
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Scientist, NeurodenerationMerck Research Laboratories 2009 - Apr 2013Kenilworth, NjSupported virtually all the internal BACE program bio-marker needs.Developed significant hands on experience in Aß bio-marker analysis with ELISA assay, generated critical data on BACE inhibitor target engagement.Execution and analysis of MK-8931 micro-hemorrhage study designed to support communications with the FDA.Validated Meso Scale CSF BACE bio-marker assays in collaboration with Merck Clinical diagnostics lab. The improved assays are now being used to support all BACE clinical studies.
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Scientist I/Ii, NeurodegenerationSchering-Plough Research Institute 1999 - 2009Kenilworth, NjPerformed core responsibility of determining BACE inhibitor IC50s with a cell based assay.Developed and Established multiple new ELISA assays for measuring sAPPb in biological samples.Set up numerous radio-ligand binding assays for counterscreens.Developed Ca+ FLUPR based primary assay for chemokine receptor signaling (e.g. CX3CR1 in microglia)Used siRNA to define the relative contributions of BACE1 and BACE2 to Aß production in HEK293 cells.Genotyping and full characterization of BACE2 knockout mouse generated from DeltagenCloning, expressing and biochemical characterization of human BACE2 in sf9 cells.
Xia Chen Skills
Xia Chen Education Details
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Beijing Normal UniversityChemistry
Frequently Asked Questions about Xia Chen
What company does Xia Chen work for?
Xia Chen works for Syneos Health (Previously Inc Research/inventiv Health)
What is Xia Chen's role at the current company?
Xia Chen's current role is Research Scientist at Syneos Health (Previously INC Research/inVentiv Health).
What is Xia Chen's email address?
Xia Chen's email address is xi****@****hoo.com
What is Xia Chen's direct phone number?
Xia Chen's direct phone number is +190822*****
What schools did Xia Chen attend?
Xia Chen attended Beijing Normal University.
What skills is Xia Chen known for?
Xia Chen has skills like Drug Discovery, Assay Development, Drug Development, Biomarkers, In Vitro, Pharmacology, High Throughput Screening, Protein Chemistry, Biochemistry, Immunoassays, Cell, Biomarker Discovery.
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Xia Chen
Transitioning Strategy Into Execution, Creating/Implementing Innovative Business/Technological Solutions, Program MgmtWashington Dc-Baltimore Area3zodiacaerospace.com, gmail.com, jostens.com1 (952) 8XXXXXXX
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