Development of medical AI-based prediction and diagnosis models

- Phases III and IV studies- Observational/RWE studies- Post-hoc analyses on RCTs- Efficacy analyses and Predictive Biomarkers research- Machine learning approach for Real Word studies- Protocol & SAP reviews

Biostatistics Consulting (Excelya)Late Phase, Real Word Research, Pharmacoepidemiology, Prospective longitudinal studies, RCT post hoc analyses

U1148 : Clinical research in atherothrombosis (Pr. P. Gabriel Steg)Biostatistical analyses of clinical data- Pharmaco - Epidemiology studies on observational registries, prospective/retrospective studies.- Post-hoc analyses on Clinical trials data- Study design, Statistical analyses plans, Statistical reports- Survivals analyses (Cox / Kaplan Meyer), Crude/adjusted Incidence rates estimations, Forest plots- Uni/Multivariate regression models (Linear, Logistic, Mixed), Propensity scores analyses, “Time varying covariates” , “Competitive Risk” models, Splines models- Diagnostic efficiency assessment, ROC curves, AUC comparison test- Student, Wilcoxon, Chi-square, Exact Fisher tests etc..- SAS (BASE/STAT/MACRO/SQL/GRAPH) & R programming

"Genome plasticity and Epigenetics" unit : Bio-analysis of Chip-Seq, Chip-CHIP, Microarray for cancer research data.Processing of new generation sequencing (NGS) dataset provided by Solid (color-space) and Solexa (base-space) , mapping, peak finding etc..Informatics lab management: Electronics Lab Notebook (ELN) and Lab management system (LIMS) setting up within the unit.

L’Oréal - Paris : Advanced Research Center : Consultant in Toxiciology Research Unit « Testing of raw products and Formulas»Protocols development for toxicology analysis, Grafical interface, VB programs and « templates » with ActivityBase (Oracle) Management & Evolution: Information Systems /R&D Departments Databases

Machine Learning on DNA chip data , clustering (K-mean, mixtures models..) enhancer sequences alignment.Work with «GeneChip core » of UCSD for statistical treatment of chip data