A2A Pharmaceuticals designs computationally optimized small molecule therapeutics for the treatment of cancer and antibiotic resistant bacterial infections. Our two oncology programs are focused on inhibiting essential protein-protein interactions in leukemia and in diverse solid tumors. These interactions are critical for cancer progression, but non-essential in normal cells. The antibiotic programs target biosynthetic enzymes in gram-negative bacteria, in pathways not found in humans. The targets selected have no clinically used therapeutics, minimizing susceptibility to resistance; and unlike the numerous follow-on antibiotics currently in development.
Our approach integrates interdisciplinary ingenuity with computational tools to design new drug candidates using our proprietary SCULPT platform. Experimentally determined target characteristics guide the selection and placement of fragments to recapitulate key contact points of proteins and/or ligands known to bind. Fragments are incorporated into the target-specific construction of combinatorial in silico libraries, which are designed based on synthetic feasibility. Libraries consisting of thousands to millions of small molecules are iteratively built, and computationally evaluated for potency and optimal ADMET properties. The final selection is made from dozens of iterations, totaling upwards of 100 million compounds.
Company Details
- Employees
- 12
- Founded
- -
- in****@****ons.com
- Industry
- Pharmaceutical Manufacturing
- NAICS
-
Pharmaceutical and Medicine ManufacturingMedicinal and Botanical ManufacturingPharmaceutical Preparation ManufacturingIn-Vitro Diagnostic Substance ManufacturingBiological Product (except Diagnostic) Manufacturing
- Website
- a2apharma.com
- Keywords
- cancer therapeutics, drug design, antibiotics.
A2a Pharmaceuticals Questions
A2A Pharmaceuticals's website is a2apharma.com
A2A Pharmaceuticals's LinkedIn profile is https://www.linkedin.com/company/a2a-pharmaceuticals
A2A Pharmaceuticals has
12 employees.
View email and phone details for 12
employees at A2A Pharmaceuticals.
A2A Pharmaceuticals's industry is
Pharmaceutical Manufacturing
A2A Pharmaceuticals's top competitors are
Jazz Pharmaceuticals,
A2a Alliance Pharmaceuticals,
Astria Therapeutics, Inc.,
A2a Integrated Pharmaceuticals,
A2a,
Accelsobio,
A2a Ambiente S.p.a.,
Volastra Therapeutics,
The Deal Mak(Her)s,
Ricovr Healthcare.
A2A Pharmaceuticals's support email address is info@atoms2applications.com
A2A Pharmaceuticals's categories are Pharmaceutical Manufacturing
A2A Pharmaceuticals's founding year is 2016
