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🔬 The importance of this project: Small Cell Lung Cancer (SCLC) poses a significant challenge in oncology, with limited treatment options and poor prognosis for patients, with a 5-year survival rate under 7%. It represents about 13%–15% of lung cancer cases; however, SCLC still lacks the benefit of personalized and effective therapies that have transformed outcomes in other types of cancer. 🎯 Our Aims: · Elucidate the proteomic significance of SCLC subtypes · Identify novel targetable proteins and proteomic pathways · Determine the genetic mutation landscape · Reveal the biological efficacy of chemotherapeutic and targeted agents · Gain insights into specific metastatic patterns of each subtype · Establish diagnostic, predictive, and prognostic biomarkers using blood-based and radiomic approaches 🌟 Why It Matters: Understanding the molecular underpinnings of SCLC is critical for developing tailored therapeutic strategies and improving patient outcomes. Our project represents a collaborative effort among esteemed institutions, including Medical University of Vienna (Medizinische Universitaet Wien), National Korányi Institute for Pulmonology (Országos Korányi Pulmonológiai Intézet), Kineto Lab. Ltd, Essen University Hospital (Universitaetsklinikum Essen), Lund University (Lunds Universitet), University of Groningen (Rijksuniversiteit Groningen), and Treat4Life AB. By pooling our expertise and resources, we aim to achieve progress in SCLC research and ultimately translate findings into clinical benefits. This project has received funding from the European Union’s Horizon Europe research and innovation program under project ID 101131228.
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