darkDNA group

We are part of the Genetics Laboratory, Biotechnology Department, School of Applied Biology and Biotechnology at the Agricultural University of Athens. Our research interests revolve around four distinct, yet intersecting, areas: --> Drug Design, Drug Repurposing and Molecular Modelling --> Genetics of Stress Mechanisms and Precision Medicine --> Exosomics, Exosome Cargo & Function, Exosome based RDTs --> Artificial Intelligence, Machine Learning and Big Data The darkDNA group encompasses all aspects of modern genetics, bioinformatics, structural and systems biology approaches. The aim is to combine multi-dimensional genomic information, to investigate complex molecular systems, heredity, population genetics and even complex diseases. In fact, the darkDNA group coalesces various fields of state of the art research in genetics into a multidiscipline approach adjusted to meet the needs of the post-Genomic era. Of particular interest is the development of statistical and computational methodologies to analyze high-throughput microarray and sequencing gene expression experiments, genetic mapping and integrate gene expression profiles, agricultural, animal and human genetics, animal biotechnology, molecular markers and complex phenotypic traits. Special emphasis is given on the development of tools to study of protein fold and structure. Our focus is also on computational statistics, stochastic search algorithms, partition modelling, Bayesian analysis of change-point models, as well as to integrate, store, organize, visualize and enhance the understanding of complex genetic and structural datasets.