With the goal of developing new therapies, the iPS Research Laboratory is a translational research group that strives to understand the mechanisms underlying human retinal pathogenesis. Our approach involves utilizing patient-derived hiPSC (human-induced pluripotent stem cells) and isogenic model lines generated through cutting-edge gene editing technologies, such as base and prime editing.
Current Research
Dr. Garita-Hernandez’s vast expertise generating hiPSC-derived retinal tissues such as various retinal organoids and RPE cells is used in projects spanning from diagnoses to modeling of inherited retinal diseases (IRDs) for validation of new therapies in a human context.
Main research topics:
1. Biomarker identification to enable accurate earlier diagnosis of IRDs.
2. Disease Modeling of inherited developmental and adult retinal disorders.
3. Gene therapy tools validation.
4. Drug discovery
The iPS Research Lab has an interdisciplinary research program that offers training on basic and advanced stem cell biology techniques on a collaborative basis.
Four Research modules are covered in a 2-year program
1. Retinogenesis
2. Disease Modeling
3. Transcriptomics
4. Gene Editing
Hands-on training includes:
1. Gene editing of iPSC lines using canonical CRISPR-Cas9, prime editing or base editing technologies.
2. Cell banking and QC of iPSC lines
3. Genotyping and sequencing analysis
4. RPE differentiation
5. Retinal Organoids generation
6. Disease modeling and phenotypic characterization
Company Details
- Address
- 243 Charles Street,
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- HQ
- Boston, Massachusetts
Ips Research Lab Questions
Ips Research Lab's website is https://oculargenomics.meei.harvard.edu/team/marcela-garita-hernandez/
Ips Research Lab's LinkedIn profile is https://www.linkedin.com/company/ips-research-lab
Ips Research Lab's industry is
Biotechnology Research
Ips Research Lab's top competitors are
Genomics Of Gene Expression Lab,
Vision Inm,
Dr Yellapragada Lifesciences,
The Institute For Neurosciences Of Montpellier,
Macular Degeneration Foundation.
Ips Research Lab's categories are Biotechnology Research
