Ophirex, Inc., a Public Benefit Corp. focused on treatments for acute, life-threatening illnesses, is modernizing the treatment of snakebite victims by developing an affordable, accessible, oral treatment for immediate use anywhere a snake’s bite occurs.
Approximately 80% of the world’s population lives in close proximity to at least one venomous snake species and more than 500,000 people are killed or maimed by snakes each year worldwide.[1][2] Field treatments could help save hundreds of thousands of lives and limbs annually and provide enormous savings in healthcare costs.[2][3]
Ophirex is developing a “time of bite” oral snakebite treatment that blocks the most commonly lethal component of snake venom—present in 95% of the world’s venomous snakes.[4] This antidote—now in human clinical trials—can be administered immediately in the field or in the hospital to effectively stop the venom’s devastating assault.[5][6][7]
1. Vulnerability to snakebite envenoming: a global mapping of hotspots. www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31224-8/fulltext
2. Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming. https://doi.org/10.1371/journal.pntd.0007059
3. Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. www.ajtmh.org/view/journals/tpmd/99/2/article-p404.xml
4. A Review and Database of Snake Venom Proteomes. https://pubmed.ncbi.nlm.nih.gov/28927001/
5. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. https://pubmed.ncbi.nlm.nih.gov/27571102/
6. Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms. www.ncbi.nlm.nih.gov/pmc/articles/PMC7076770/
7. Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite (BRAVO).
https://clinicaltrials.gov/ct2/show/NCT04996264
Company Details
- Employees
- 25
- Founded
- -
- Address
- Corte Madera, Ca 94925, Us
- Industry
- Biotechnology
- Website
- https://www.ophirex.com/
- Keywords
- Boston.
- HQ
- Corte Madera, CA
Ophirex, Inc. Questions
Ophirex, Inc.'s website is https://www.ophirex.com/
Ophirex, Inc.'s LinkedIn profile is https://www.linkedin.com/company/ophirex
Ophirex, Inc. has
25 employees.
View email and phone details for 25
employees at Ophirex, Inc..
Ophirex, Inc.'s industry is
Biotechnology
Ophirex, Inc.'s top competitors are
Maplight Therapeutics, Inc.,
Seawolf Therapeutics, Inc.,
Insmed Incorporated,
An2 Therapeutics,
Sangamo Therapeutics, Inc.,
Lindus Health,
Invivyd,
Poseida Therapeutics, Inc.,
Recode Ventures.
Ophirex, Inc.'s categories are Biotechnology
Ophirex, Inc.'s founding year is 2015
