Talus Bio

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Talus Bio is making the regulome visible and druggable. We are building the first platform to map, model, and ultimately write the regulome, unlocking thousands of previously undruggable targets, including transcription factors that drive cancer, autoimmunity, and neurodegeneration. Our platform measures the regulome directly in living human cells, generating functional datasets at scale for the first time. These data fuel AI models that learn the logic of genome regulation and predict how to modulate it with precision.

Company Details

Employees
27
Founded
-
Address
550 17th Ave,
Industry
Biotechnology Research
NAICS
Research and Development in Biotechnology (except Nanobiotechnology)
Keywords
to Talus Bio..
HQ
Seattle, WA
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Talus Bio Presents Preclinical Data on Transcription Factor Therapeutic Programs at the AACR Annual Meeting 2025 - Business Wire

Talus Bio Presents Preclinical Data on Transcription Factor Therapeutic Programs at the AACR Annual Meeting 2025 Business Wire

Talus Bio tacks on $11M to target hard-to-reach transcription factors - Fierce Biotech

Talus Bio tacks on $11M to target hard-to-reach transcription factors Fierce Biotech

Diagnostic accuracy of plain radiographs compared to CT scans in classifying talus injuries - BMC Musculoskeletal Disorders

Diagnostic accuracy of plain radiographs compared to CT scans in classifying talus injuries BMC Musculoskeletal Disorders

From Data to Drugs: The Role of Artificial Intelligence in Drug Discovery - Wyss Institute at Harvard

From Data to Drugs: The Role of Artificial Intelligence in Drug Discovery Wyss Institute at Harvard

After layoffs, a viral immunotherapy biotech bounced back with a late-stage prostate cancer win - Pharma Voice

After layoffs, a viral immunotherapy biotech bounced back with a late-stage prostate cancer win Pharma Voice

Comparison of medial osteochondral lesions of the talus characteristics between chronic lateral ankle instability and ankle varus - Journal of Orthopaedic Surgery and Research

Comparison of medial osteochondral lesions of the talus characteristics between chronic lateral ankle instability and ankle varus Journal of Orthopaedic Surgery and Research

Tech Moves: Flexe taps new CTO; Talus adds head of biology; Vouched names a sales VP - GeekWire

Tech Moves: Flexe taps new CTO; Talus adds head of biology; Vouched names a sales VP GeekWire

Talus brings in $11.2M to target the undruggable - BioWorld MedTech

Talus brings in $11.2M to target the undruggable BioWorld MedTech

A biotech tackles drug discovery with transcription factor know-how - Pharma Voice

A biotech tackles drug discovery with transcription factor know-how Pharma Voice

To turn off disease-causing genes, Talus Bio wants to knock proteins off of DNA - Fierce Biotech

To turn off disease-causing genes, Talus Bio wants to knock proteins off of DNA Fierce Biotech

Omri Drory, Ph.D. - NFX

Omri Drory, Ph.D. NFX

Is Proteomics the Next Big "Ome"? - Genetic Engineering and Biotechnology News

Is Proteomics the Next Big "Ome"? Genetic Engineering and Biotechnology News

Subchondral bone density changes of the talus in dogs with tarsocrural osteochondrosis - BMC Veterinary Research

Subchondral bone density changes of the talus in dogs with tarsocrural osteochondrosis BMC Veterinary Research

The Week in AgriFoodTech: Talus Renewables nabs $22m for green ammonia, Getir buys FreshDirect - AgFunderNews

The Week in AgriFoodTech: Talus Renewables nabs $22m for green ammonia, Getir buys FreshDirect AgFunderNews

Seattle biotech startup secures $11.2M to make drugs for ‘undruggable’ disease targets - GeekWire

Seattle biotech startup secures $11.2M to make drugs for ‘undruggable’ disease targets GeekWire

Roche teams up with transcription factor trailblazer Flare in new $1.8B-plus cancer pact - Fierce Biotech

Roche teams up with transcription factor trailblazer Flare in new $1.8B-plus cancer pact Fierce Biotech

Talus Bioscience lands $4.3M in grant funding for drug discovery platform - GeekWire

Talus Bioscience lands $4.3M in grant funding for drug discovery platform GeekWire

Inspired by scientist CEOs, Seattle startup lands $9.75M to build up drug discovery platform - GeekWire

Inspired by scientist CEOs, Seattle startup lands $9.75M to build up drug discovery platform GeekWire

Designing and additive manufacturing of talus implant for post-traumatic talus avascular necrosis: a case study - Journal of Orthopaedic Surgery and Research

Designing and additive manufacturing of talus implant for post-traumatic talus avascular necrosis: a case study Journal of Orthopaedic Surgery and Research

Comparative cross-sectional study of optimal screw positioning in the talus during arthroscopic ankle arthrodesis: a computed tomography-based analysis of talar bone density - BMC Musculoskeletal Disorders

Comparative cross-sectional study of optimal screw positioning in the talus during arthroscopic ankle arthrodesis: a computed tomography-based analysis of talar bone density BMC Musculoskeletal Disorders

The biggest US biotech investments in June 2022 - Labiotech.eu

The biggest US biotech investments in June 2022 Labiotech.eu

nf-encyclopedia: A Cloud-Ready Pipeline for Chromatogram Library Data-Independent Acquisition Proteomics Workflows - ACS Publications

nf-encyclopedia: A Cloud-Ready Pipeline for Chromatogram Library Data-Independent Acquisition Proteomics Workflows ACS Publications

Three-dimensional printed custom-made modular talus prosthesis in patients with talus malignant tumor resection - Journal of Orthopaedic Surgery and Research

Three-dimensional printed custom-made modular talus prosthesis in patients with talus malignant tumor resection Journal of Orthopaedic Surgery and Research

Different radius of curvature at the talus trochlea from northern Chinese population measured using 3D model - Journal of Orthopaedic Surgery and Research

Different radius of curvature at the talus trochlea from northern Chinese population measured using 3D model Journal of Orthopaedic Surgery and Research

Results of treatment of congenital vertical talus by the Dobbs method - Journal of Orthopaedic Surgery and Research

Results of treatment of congenital vertical talus by the Dobbs method Journal of Orthopaedic Surgery and Research

Covalent Labeling Automated Data Analysis Platform for High Throughput in R (coADAPTr): A Proteome-Wide Data Analysis Platform for Covalent Labeling Experiments - ACS Publications

Covalent Labeling Automated Data Analysis Platform for High Throughput in R (coADAPTr): A Proteome-Wide Data Analysis Platform for Covalent Labeling Experiments ACS Publications

The Kilimanjaro Climb to Fight Cancer Is Back - Timmerman Report

The Kilimanjaro Climb to Fight Cancer Is Back Timmerman Report

CRISPR’s cardio catch-all drives a biotech’s broad potential - Pharma Voice

CRISPR’s cardio catch-all drives a biotech’s broad potential Pharma Voice

Kirkland-based Resolution Bioscience closing 2 years after Agilent acquisition - The Business Journals

Kirkland-based Resolution Bioscience closing 2 years after Agilent acquisition The Business Journals

SPECT/CT imaging features of cystic degeneration of the talus and their relation to pathological findings - Journal of Orthopaedic Surgery and Research

SPECT/CT imaging features of cystic degeneration of the talus and their relation to pathological findings Journal of Orthopaedic Surgery and Research

Riding the mRNA wave, HDT Bio closes in on cancer-fighting vaccine - Pharma Voice

Riding the mRNA wave, HDT Bio closes in on cancer-fighting vaccine Pharma Voice

Fracture of the lateral process of the talus with associated deltoid ligament injury: a report of 2 cases - BMC Surgery

Fracture of the lateral process of the talus with associated deltoid ligament injury: a report of 2 cases BMC Surgery

Founder-led biotech is making space for ideas—and diverse leaders—where it didn't exist before - Fierce Biotech

Founder-led biotech is making space for ideas—and diverse leaders—where it didn't exist before Fierce Biotech

Asia-based financial group launches $50M US biotech fund - Fierce Biotech

Asia-based financial group launches $50M US biotech fund Fierce Biotech

Comparative study of arthroscopic autologous cancellous bone grafting and medial malleolar osteotomy combined with autologous periosteal iliac bone grafting for the treatment of osteochondral lesions of the talus - Journal of Orthopaedic Surgery and Research

Comparative study of arthroscopic autologous cancellous bone grafting and medial malleolar osteotomy combined with autologous periosteal iliac bone grafting for the treatment of osteochondral lesions of the talus Journal of Orthopaedic Surgery and Research

Medial malleolar osteotomy in the treatment of osteochondral lesions of the Talus – incidence and impact on functional outcome: a retrospective analysis based on data from the German Cartilage Register (KnorpelRegister DGOU) - BMC Musculoskeletal Disorders

Medial malleolar osteotomy in the treatment of osteochondral lesions of the Talus – incidence and impact on functional outcome: a retrospective analysis based on data from the German Cartilage Register (KnorpelRegister DGOU) BMC Musculoskeletal Disorders

The effect of talus osteochondral defects of different area size on ankle joint stability: a finite element analysis - BMC Musculoskeletal Disorders

The effect of talus osteochondral defects of different area size on ankle joint stability: a finite element analysis BMC Musculoskeletal Disorders

Protein power: a biotech mining viruses to fight disease - Pharma Voice

Protein power: a biotech mining viruses to fight disease Pharma Voice

Biotech spotlight: Twist Bioscience aims to remove limits on drug discovery with DNA synthesis platform - Pharma Voice

Biotech spotlight: Twist Bioscience aims to remove limits on drug discovery with DNA synthesis platform Pharma Voice

Avascular necrosis of the talus causing meniscoid lesions in the ankle joint: a case report - Journal of Medical Case Reports

Avascular necrosis of the talus causing meniscoid lesions in the ankle joint: a case report Journal of Medical Case Reports

Mining clues from a library of brain tissue samples, Cerevance takes a precision approach to CNS disorders - Pharma Voice

Mining clues from a library of brain tissue samples, Cerevance takes a precision approach to CNS disorders Pharma Voice

AstraZeneca pays Hoos-helmed Scorpion $75M to take the sting out of undruggable cancer targets - Fierce Biotech

AstraZeneca pays Hoos-helmed Scorpion $75M to take the sting out of undruggable cancer targets Fierce Biotech

Clinical significance of the anteromedial talus osteophyte in anteromedial ankle impingement in chronic lateral ankle instability - Journal of Orthopaedic Surgery and Research

Clinical significance of the anteromedial talus osteophyte in anteromedial ankle impingement in chronic lateral ankle instability Journal of Orthopaedic Surgery and Research

Brii Biosciences aims to come up big where Sage and Biogen fell short - Pharma Voice

Brii Biosciences aims to come up big where Sage and Biogen fell short Pharma Voice

MRI and single-cell RNA sequence results reveal the influence of anterior talofibular ligament injury on osteochondral lesions of the talus - Journal of Orthopaedic Surgery and Research

MRI and single-cell RNA sequence results reveal the influence of anterior talofibular ligament injury on osteochondral lesions of the talus Journal of Orthopaedic Surgery and Research

A biotech’s difficult journey to bring a new kind of Parkinson’s drug to patients - Pharma Voice

A biotech’s difficult journey to bring a new kind of Parkinson’s drug to patients Pharma Voice

Efficacy of platelet-rich plasma use as an adjunctive treatment in autologous osteochondral transplantation for patients with osteochondral lesions of the talus accompanied by chronic lateral ankle instability - Journal of Orthopaedic Surgery and Research

Efficacy of platelet-rich plasma use as an adjunctive treatment in autologous osteochondral transplantation for patients with osteochondral lesions of the talus accompanied by chronic lateral ankle instability Journal of Orthopaedic Surgery and Research

Venture firm raising $30 million fund targeted at founders with UW ties - The Business Journals

Venture firm raising $30 million fund targeted at founders with UW ties The Business Journals

Mythic Therapeutics aims to overcome one of ADC’s long-standing challenges - Pharma Voice

Mythic Therapeutics aims to overcome one of ADC’s long-standing challenges Pharma Voice

Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial - BMC Musculoskeletal Disorders

Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial BMC Musculoskeletal Disorders

Black Diamond looks to outwit cancer mutations - Pharma Voice

Black Diamond looks to outwit cancer mutations Pharma Voice

Triplane osteotomy combined with talar non-weight-bearing area autologous osteochondral transplantation for osteochondral lesions of the talus - BMC Musculoskeletal Disorders

Triplane osteotomy combined with talar non-weight-bearing area autologous osteochondral transplantation for osteochondral lesions of the talus BMC Musculoskeletal Disorders

Biomechanical efficacy of four different dual screws fixations in treatment of talus neck fracture: a three-dimensional finite element analysis - Journal of Orthopaedic Surgery and Research

Biomechanical efficacy of four different dual screws fixations in treatment of talus neck fracture: a three-dimensional finite element analysis Journal of Orthopaedic Surgery and Research

Gracell Biotechnologies’ quest to unlock the CAR-T bottleneck - Pharma Voice

Gracell Biotechnologies’ quest to unlock the CAR-T bottleneck Pharma Voice

How OliX Pharmaceuticals is riding the RNAi wave - Pharma Voice

How OliX Pharmaceuticals is riding the RNAi wave Pharma Voice

Natural course of talar avascular necrosis during short-term follow-up and factors associated with Disease progression - BMC Musculoskeletal Disorders

Natural course of talar avascular necrosis during short-term follow-up and factors associated with Disease progression BMC Musculoskeletal Disorders

New, Inclusive VC Fund Targets UW Innovators - 425business.com

New, Inclusive VC Fund Targets UW Innovators 425business.com

Moma Therapeutics aims at molecular machines with $86M raise - Fierce Biotech

Moma Therapeutics aims at molecular machines with $86M raise Fierce Biotech

Single-cell RNA sequence presents atlas analysis for chondrocytes in the talus and reveals the potential mechanism in coping with mechanical stress - Frontiers

Single-cell RNA sequence presents atlas analysis for chondrocytes in the talus and reveals the potential mechanism in coping with mechanical stress Frontiers

Electromagnetic navigation reduces radiation exposure for retrograde drilling in osteochondrosis dissecans of the talus - BMC Musculoskeletal Disorders

Electromagnetic navigation reduces radiation exposure for retrograde drilling in osteochondrosis dissecans of the talus BMC Musculoskeletal Disorders

An ‘inverse vaccine’ takes aim at autoimmune diseases - Pharma Voice

An ‘inverse vaccine’ takes aim at autoimmune diseases Pharma Voice

Emalex aims at a first-in-class breakthrough for Tourette syndrome - Pharma Voice

Emalex aims at a first-in-class breakthrough for Tourette syndrome Pharma Voice

TwinStrand names Ron Andrews as permanent CEO after 2022 leadership shuffle - The Business Journals

TwinStrand names Ron Andrews as permanent CEO after 2022 leadership shuffle The Business Journals

A comparison between arthroscopic and open surgery for treatment outcomes of chronic lateral ankle instability accompanied by osteochondral lesions of the talus - Journal of Orthopaedic Surgery and Research

A comparison between arthroscopic and open surgery for treatment outcomes of chronic lateral ankle instability accompanied by osteochondral lesions of the talus Journal of Orthopaedic Surgery and Research

Effect analysis of iliac bone autografting for Hepple V osteochondral lesions of the talus - Journal of Orthopaedic Surgery and Research

Effect analysis of iliac bone autografting for Hepple V osteochondral lesions of the talus Journal of Orthopaedic Surgery and Research

(PDF) Neglected paediatric talus neck fracture - researchgate.net

(PDF) Neglected paediatric talus neck fracture researchgate.net

Polychain-backed Talus Network Launches Nexus: The First Fully Onchain Agentic Framework for Autonomous AI on Blockchain - Decrypt

Polychain-backed Talus Network Launches Nexus: The First Fully Onchain Agentic Framework for Autonomous AI on Blockchain Decrypt

Arthroscopic reduction and internal fixation for fracture of the posterior process of the talus (Shepherd’s fracture): a case report - Journal of Medical Case Reports

Arthroscopic reduction and internal fixation for fracture of the posterior process of the talus (Shepherd’s fracture): a case report Journal of Medical Case Reports

Humane Genomics is 3D-printing oncolytic viruses to treat rare cancers - Fierce Biotech

Humane Genomics is 3D-printing oncolytic viruses to treat rare cancers Fierce Biotech

Newly-formed Seattle VC firm aims to mine Univ. of Washington network for talent, innovation, money - GeekWire

Newly-formed Seattle VC firm aims to mine Univ. of Washington network for talent, innovation, money GeekWire

Clinical presentation and surgical treatment of distal fibular non-union with talus chondral lesions in a pediatric patient: a case report - BMC Surgery

Clinical presentation and surgical treatment of distal fibular non-union with talus chondral lesions in a pediatric patient: a case report BMC Surgery

Uli Chi named a PSBJ Director of the Year - The Business Journals

Uli Chi named a PSBJ Director of the Year The Business Journals

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