Trellis Bioscience is a clinical-stage company focused on discovering and developing native human monoclonal antibodies to treat and prevent drug-resistant, life-threatening infectious diseases. Antibodies are the immune system's most potent natural weapon against disease. Trellis's innovative proprietary technology CellSpot™ overcomes technical obstacles that have long hindered exploiting the full human antibody repertoire. This ideal source of drugs focuses on the selection of elite antibodies that bind highly conserved target epitopes with
high affinity.
TRL1068 is a native human monoclonal antibody (for intravenous delivery) whose target is a family of bacterial proteins (DNABII) that play a critical role in maintaining the structural integrity of biofilms by anchoring extracellular bacterial DNA (eDNA) from dead bacteria within the biofilm matrix. TRL1068 binds at high affinity (Kd ~50 pM) to a highly conserved epitope found in nearly all medically significant bacteria, including both Gram-positive and Gram-negative species. High affinity binding to DNABII ensures that the protein is eliminated from the body and thus prevents its deposition elsewhere in the body, where it could form biofilm metastases. Because the bacterial target is only exposed to the antibody after the producing bacterial cell is dead, resistance to this novel intervention is expected to be rare. The FDA granted Fast Track, QIDP (qualified infectious disease product), and Orphan Drug designations for TRL1068.
Company Details
- Employees
- 19
- Address
- 702 Marshall St, Redwood City,california 94063,united States
- Phone
- (650)616-1100
- mm****@****bio.com
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- Website
- trellisbio.com
- Keywords
- Austin.
- HQ
- Redwood City, California
Trellis Bioscience Inc. Questions
Trellis Bioscience Inc.'s helpline number is (650)616-1100
Trellis Bioscience Inc.'s website is trellisbio.com
Trellis Bioscience Inc.'s LinkedIn profile is https://www.linkedin.com/company/trellis-bioscience
Trellis Bioscience Inc. has
19 employees.
View email and phone details for 19
employees at Trellis Bioscience Inc..
Trellis Bioscience Inc.'s industry is
Biotechnology Research
Trellis Bioscience Inc.'s top competitors are
Sumaya Biotech Gmbh & Co. Kg,
Cynch Ai,
Visionscope Technologies,
Celid Biotechnologies Inc.,
Navera,
Bristol Myers Squibb,
Gilead Sciences,
Veridata,
Scale Point Solutions,
Lenvayo.
Trellis Bioscience Inc.'s support email address is mmoncada@trellisbio.com
Trellis Bioscience Inc.'s categories are Biotechnology Research
