Joshua Abbott Email and Phone Number
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Joshua Abbott is a Senior Scientist, Biophysics & Biochemistry at Rapafusyn Pharmaceuticals. He possess expertise in chemistry, research, data analysis, hplc, public speaking and 14 more skills. He is proficient in Spanish.
Rapafusyn Pharmaceuticals
View- Website:
- rapafusyn.com
- Employees:
- 7
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Senior Scientist IiRapafusyn Pharmaceuticals Apr 2023 - PresentWashington Dc-Baltimore Area
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Senior ScientistRapafusyn Pharmaceuticals Jul 2022 - Apr 2023Washington Dc-Baltimore Area
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Postdoctoral FellowNational Center For Advancing Translational Sciences (Ncats) Apr 2020 - Jul 2022Rockville, Maryland, United States• Biomarker and drug target discovery using RNA-seq and proteomics of patient derived tissue models.• Performed drug target validation using siRNA, shRNA, RNA-seq, and proteomic profiling to characterize disease mechanisms. Validation of biomarkers using qPCR and western blotting.• High-content analysis of neural stem cells, iPSCs, and brain organoids to characterize and validate drug targets and biomarkers.• Designed antisense oligonucleotides and evaluated their efficacy for exon… Show more • Biomarker and drug target discovery using RNA-seq and proteomics of patient derived tissue models.• Performed drug target validation using siRNA, shRNA, RNA-seq, and proteomic profiling to characterize disease mechanisms. Validation of biomarkers using qPCR and western blotting.• High-content analysis of neural stem cells, iPSCs, and brain organoids to characterize and validate drug targets and biomarkers.• Designed antisense oligonucleotides and evaluated their efficacy for exon skipping in in vitro models.• Developed bioinformatics analysis pipelines for RNA-seq and global proteomic profiling analysis using R.• Utilized CRISPR/CAS9 in patient derived iPSCs characterize disease mechanisms. Show less -
Phd CandidateUniversity Of Colorado Anschutz Medical Campus Aug 2015 - Mar 2020Greater Denver Area• Developed in vitro assays to characterize inhibition of chromatin remodeling using biophysical, biochemical, and cell-based methods.• Expressed and purified multiple constructs of CHD1L from E. coli.• Evaluated the impact of CHD1L expression in colorectal cancer patients using RNA-seq and microarray data.• Characterized the function of CHD1L on TCF-transcription using RNA silencing and gene overexpression.• Developed an CHD1L in vitro assay and carried high-throughput screen… Show more • Developed in vitro assays to characterize inhibition of chromatin remodeling using biophysical, biochemical, and cell-based methods.• Expressed and purified multiple constructs of CHD1L from E. coli.• Evaluated the impact of CHD1L expression in colorectal cancer patients using RNA-seq and microarray data.• Characterized the function of CHD1L on TCF-transcription using RNA silencing and gene overexpression.• Developed an CHD1L in vitro assay and carried high-throughput screen (20,000 compounds) using automated liquid handling (PerkinElmer Janus).• Identified small molecule inhibitors of CHD1L and characterized their activity using biochemistry, cell biology, and 3D high-content analysis using tumor organoid models (PerkinElmer Opera Phenix). Show less -
Research TechnicianUniversity Of Michigan Medical School Sep 2013 - Aug 2015Ann Arbor, Mi• Characterized inhibitors of histone methyltransferases NSD1, NSD2, and NSD3 as well as BCL6 .• Expressed and purified multiple histone methyltransferase proteins for enzyme assays and structural biology efforts.• Utilized biophysical methods (NMR, x-ray crystallography, isothermal calorimetry, computer aided drug design) to characterize small molecule-protein interactions.• Structure-based computational drug design using Discovery studios and molecular dynamics simulations. -
Community CoordinatorPartners In Health Sep 2013 - Jul 2015Ann Arbor, MiWorking with PIH Engage to build local communities dedicated to education and advocacy for global health and health inequality issues. -
Research AssistantKalamazoo College May 2013 - Sep 2013Kalamazoo, Michigan AreaWorked in the Smith lab synthesizing a series of marcocyclic vanadium compounds to understand the influence on molecular structure and electrophysical properties. -
Teaching AssistantKalamazoo College Aug 2012 - Mar 2013In lab teaching assistant and grader for Organic Chemistry I and II.
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Research AssistantUniversity Of Michigan Medical School Jun 2012 - Aug 2012Ann Arbor, MiWorked in the Paul Hollenberg's lab in the Department of Pharmacology at a part of the NSF sponsored Interdisciplinary Structure and Function of Proteins REU program. Research focused on the P450 CYP2B6 and its polymorphisms. I helped to develop an in-vitro assay to detect the metabolism of cyclophosphamide by CYP2B6 using fluorescence coupled with HPLC.
Joshua Abbott Skills
Joshua Abbott Education Details
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Biochemistry And Structural Biology
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Chemistry, Biological Physics, Biochemistry And Molecular Biology
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Orchard Lake St. Mary'S PreparatoryHigh School Diploma
Frequently Asked Questions about Joshua Abbott
What company does Joshua Abbott work for?
Joshua Abbott works for Rapafusyn Pharmaceuticals
What is Joshua Abbott's role at the current company?
Joshua Abbott's current role is Senior Scientist, Biophysics & Biochemistry.
What is Joshua Abbott's email address?
Joshua Abbott's email address is jo****@****ver.edu
What schools did Joshua Abbott attend?
Joshua Abbott attended University Of Colorado Anschutz Medical Campus, Kalamazoo College, Orchard Lake St. Mary's Preparatory.
What skills is Joshua Abbott known for?
Joshua Abbott has skills like Chemistry, Research, Data Analysis, Hplc, Public Speaking, Organic Chemistry, Protein Chemistry, Nmr, Molecular Biology, Nmr Spectroscopy, Statistics, Laboratory.
Who are Joshua Abbott's colleagues?
Joshua Abbott's colleagues are Sam Hong, Wojtek Michowski, Shida M., Heather Lavin.
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Joshua A.
Ceo | Growth-Focused It Partner | Delivering Strategic, Proactive Technology SolutionsDenham Springs, La5goskyhawk.com, gmail.com, goskyhawk.com, skyhawkgrp.com, twenty20solutions.com2 +122530XXXXX
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Joshua Abbott
Professor And Director, School Of Sustainability, Arizona State UniversityGreater Phoenix Area -
Joshua Abbott
Columbus, Oh1abb.com -
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