Bérénice C. Email & Phone Number

United Kingdom

Ottawa, Ontario, Canada

Research project: Developing innovative strategies to treat paroxysmal atrial fibrillation using extracellular vesicles.Relevant publications:• Collet B. & Davis D.R., 2023. Mechanisms of Cardiac Repair in Cell Therapy. Heart, Lung, and Circulation. doi:10.1016/j.hlc.2023.01.019Main objectives:• Design of an in vivo model of atrial fibrillation (mouse and rat).• Evaluation of EVs uptake by various cellular cell types* through flow cytometry (in vitro).*[atrial fibroblasts (rats), heart explant-derived cells (humans), HEK cells, HEPG2, HPMECs, HUVECs, macrophages, NRVMs, SK-N-SH] • Prevention and treatment study: EVs beneficial effects in regards with atrial fibrillation (in vivo).Cardiac Translational Research Laboratory, Dr Darryl Davis laboratory

Amsterdam, Hollande Septentrionale, Pays-Bas

Research project: Effect-Based Analysis of Endocrine Disrupting Chemical Mixtures in Breast Milk and Possible Health Consequences for Human Infants. Thesis Available Online: https://research.vu.nl/en/publications/a9592017-ec7b-4bd1-bc6f-f00a4af7b07dMember of the Marie Sklodowska-Curie: Innovative Training Networks (ITN) ProtectED.Relevant publications:• Desalegn A., Collet B., Iszatt N., Stigum H., Jensen T., Jonker L., Van der Burg B., and Eggesbø M., 2022. Aryl Hydrocarbon Receptor Activity in Human Breast Milk and Cryptorchidism: A Case-Control Study within the Prospective Norwegian HUMIS Cohort. Environ Res 214:113861; doi:10.1016/j.envres.2022.113861 (impact factor 6.5) • Collet B., Desalegn A., Swart K., Naderman M., Iszatt N., Stigum H., Jensen T., Brouwer A., Eggesbø M., and Van der Burg B., 2021. Anti-Androgenic Compounds in Breast Milk and Cryptorchidism Among Norwegian Boys in the HUMIS Birth Cohort. Science of the Total Environment 803; doi.org/10.1016/j.scitotenv.2021.149746 (impact factor 7.9)• Collet B., Van Vugt-Lussenburg BMA, Swart K., Helmus R., Naderman M., De Rijke E., Eggesbø M., Brouwer A. and Van der Burg B., 2020. Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort. Environ Int 143:105948; doi:10.1016/j.envint.2020.105948. (impact factor 7.5)• Collet B., Simon E., Van der Linden S., el Abdellaoui N., Naderman M., Man HY, Middelhof I., Van der Burg B., Besselink H., and Brouwer A., 2019. Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities. Reprod Toxicol 1–13; doi:10.1016/j.reprotox.2019.05.011. (impact factor 3.1)

Dr. Martine Culty'S Laboratory, Montréal, Canada

Research project: Effects of an early-life exposure to DEHP and genistein exposure on testis development and function. (Rattus norvegicus)Relevant publication:Walker C, Ghazisaeidi S, Collet B, Boisvert A, Culty M. 2020. In‐utero Exposure to Low Doses of Genistein and Di‐(2‐ethylhexyl) Phthalate (DEHP) Alters Innate Immune Cells in Neonatal and Adult Rat Testis. Andrology 1–22; doi:10.1111/andr.12840. (impact factor 3.8)Main objectives:- Animal (rats) exposure to a mixture of endocrine disruptors through gavage followed by sacrifice and tissue collection.- Examination of global DNA methylation profiles.- General molecular laboratory methods (q-PCR, Immunohistochemistry, RNA Extraction, cDNA synthesis,...).- Identifation of target genes by analyzing gene arrays, validation by q-PCR and IHC/IF.

Dr. Ina Dobrinski'S Laboratory, Calgary, Canada

Research project: In vitro germline differentiation of induced Pluripotent Stem Cells (iPSC) in a large animal model, the pig : Sus scrofa.Main objectives:- Cell culture (iPSCs, mouse fibroblasts and HEK 293 cells)- Characterization of pig iPSCs (Immunocytochemistry using pluripotent markers, fluorescence microscopy...)- Construction of a reporter vector (Molecular cloning, PCR Screening...) https://vet.ucalgary.ca/profiles/ina-dobrinski

Phd In Biology, Reproductive Toxicology

• Collet B., 2021. (Thesis) Effect-Based Analysis of Endocrine Disrupting Chemical Mixtures in Breast Milk and Possible Health.

Master Of Science - Ms, Biotechnology - Molecular & Cellulaire Engineering

Activities and Societies: Vice-president of the student organisation ''BDE Biotechnology : Genomics and Proteomics'' (1 year) Main.

Bachelor Degree, Cellular Biology And Physiology

Activities and Societies: Active member and graphics designer of the student organisation ''BDE Biology'' (3 years) Main subjects.