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Industry ExpertiseSuccessful Project Management-Recognize risk and propose contingency plans-In-depth, scientific-directed, innovative thinker-Spotfire analysis to identify interrelationships of variables, processes and systems-Accomplished large dataset analysisProven scientific track record -Novel HBV drug discovery platform-1 oligonucleotide program; Project Team Leader-1 small molecule program; Lead Scientist-Novel target identification and validation-4 Publications-6 PatentsTacit Knowledge of Technology-Highthroughput Screening-iPSC Derived Hepatocytes-Primary Human Hepatocytes-RNAi genome editing-LNA Antisense Oligonucleotide, shRNA, siRNA-Assay development and implementation-Small Molecule SAR-Agilent Bravo Robotics-Attune FACs-WES capillary based westerns-Fluidigm microfluidic qPCR-Digital PCR-Luminex FlexMap3D
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FounderDiscovery BlueprintNew York, Ny, Us
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Principal ScientistYarrow Biotechnology, IncNew York, Ny, Us -
Senior ScientistYarrow Biotechnology Sep 2021 - PresentNew York, New York, United StatesYarrow is an early stage RTW-incubated company developing therapeutics for autoimmune disease
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Lead R&D SpecialistRegeneron Pharmaceuticals, Inc. Oct 2019 - Sep 2021Tarrytown, New YorkViral Vector Technologies and Infectious Disease➢ In vitro human liver disease modeling➢CRISPR/Cas9-mediated targeted transgene insertion in the liver➢Expertise in humanized mouse liver model -
Senior Scientist And Project Team LeaderRoche Oct 2015 - Sep 2019Basel Area, SwitzerlandImmunology, Inflammation and Infectious DiseasesDiscovery VirologySmall Molecule and SSO screening for viral suppression on novel in vitro Hepatitis B Virus infection platform; focus on HBV cure and cccDNA destabilizersAssay development/implementation using iPSC-derived hepatocytes and primary human hepatocytes -
Principal Associate ScientistRoche Sep 2013 - Oct 2015Basel Area, SwitzerlandImmunology, Inflammation and Infectious DiseasesDiscovery Molecular VirologyAssay development using pluripotent stem cell derived hepatocytesCompound library screening for small molecules capable of viral suppression -
Senior Associate ScientistRoche Pharmaceuticals Jun 2010 - Sep 2013Non-Clinical Safety Stem Cell LabLaboratory of Applied Safety ScienceHighthroughput Compound Library Screening for small molecules capable of modulating cellular phenotype.(pluripotent stem cell derived hepatocytes, cardiomyocytes)Derivation of model species(Cynomolgus,Canine) induced pluripotent stem cell lines3D cell culture expertise(Cell Asic, Alvetex, LiverChip, RealBio)Flow Cyometry expertise: analysis and single Cell sorting(BD FACSAriaII,ABI Attune) -
Life Science Research AssistantStanford Oct 2007 - Jun 2010Strong foundation in human pluripotent stem cell research with extensive knowledge of human embryonic stem cell (hESC) maintenance and propagation. Generated and characterized 3 independent induced pluripotent stem cell lines (iPSC) from patients with varying severity of Marfan syndrome. In vitro research to study the development of the disease by differentiation towards clinically relevant tissues. Differentiation of hESC/iPSCs to mesenchymal stem cells and isolatation by FACs for subpopulations of mesenchymal progenitors for terminal differentiation. Researching hESC/iPSC-derived mesenchymal stem cells ability to enter the myogenic program and differentiate to mature skeletal muscle.
Brian Leonard Skills
Brian Leonard Education Details
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Biopharma Innovation -
Biology
Frequently Asked Questions about Brian Leonard
What company does Brian Leonard work for?
Brian Leonard works for Discovery Blueprint
What is Brian Leonard's role at the current company?
Brian Leonard's current role is Founder.
What is Brian Leonard's email address?
Brian Leonard's email address is br****@****ron.com
What schools did Brian Leonard attend?
Brian Leonard attended Rutgers Graduate School Of Management, Niagara University.
What are some of Brian Leonard's interests?
Brian Leonard has interest in Going To Sporting Events, Team Work Atmostphere (Sports Or Office), Fishing, Community Service.
What skills is Brian Leonard known for?
Brian Leonard has skills like Stem Cells, Cell Based Assays, Life Sciences, Research, In Vitro, Molecular Biology, Cell Culture, Protein Purification, Cell Biology, Elisa, Flow Cytometry, Bioinformatics.
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Brian Leonard
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Brian Leonard
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