Brian Day Email & Phone Number

Alexandria, Va, Us

Rockville, Maryland, United States

• Synthesized and developed novel anti-cancer payload molecules, linker-payloads, and antibody-drug conjugate therapeutics in a research and development environment, independently.• Performed site-specific and non-specific antibody conjugations to attain ADCs with the desired DAR and characterized therapeutics by chromatography (SEC, HIC, and HPLC-MS).• Analyzed pharmacokinetic, conjugation, and toxicity cell data and modified linker-payloads to improve in vitro properties.• Developed novel polymer, peptide, and sugar linker pieces to improve solubility and release of payload.• Coordinated product development with multi-departmental teams (protein engineers and cell assay scientist) and contract research organizations (CRO).• Supervised junior chemists on project goals, method development, and safe synthetic practices. • Performed patent analysis to identify viable chemical space to pursue targets and contributed to the development of the experimental section in three patents.

Wake Forest, North Carolina, United States

• Analyzed and reported LC-MS/MS data of clinically prescribed drugs and drugs of abuse via Sciex services, remotely. • Served in a client-facing role and worked with companies to understand data reporting methods/criteria.• Ensured that results met quality control standards in line with criteria established by the SOP. • Collaborated with laboratory-based teams to communicate instrument or data issues. • Trained junior analysts on resolving instrumentation issues and reporting data.

Philadelphia, Pennsylvania, United States

• Performed projects for Praeventix (a start-up biotechnology company) while employed at Temple University. • Synthesized and developed novel small molecule pharmaceutics and analyzed physicochemical and in vitro data.• Characterized therapeutics by NMR, HPLC-MS, and FTIR.• Developed HPLC-UV-Vis and LC-MS/MS methodology to detect lipid nanoparticle drug concentrations and lower limit of detection. • Analyzed patents for pursuable projects by inspecting chemical space and utilizing the privileged scaffold approach.

Chantilly, Virginia, United States

• Performed large batch sample preparation for drug screening through manual and automated extractions and processed resulting data by LC-MS/MS through Sciex services to detect the recent use of 51 analytes per sample. • Analyzed biological samples by immunoassay for total protein, 17 specific protein, and 4 tumor marker antigen concentrations. • Completed instrument and QC validations to ensure data integrity.• Assisted R&D department with SOP revisions and preparations to transition to a new oral fluid collection device.

Master Of Science - Ms, Medicinal And Pharmaceutical Chemistry

Bachelor Of Science - Bs, Biochemistry